Diabody is a noncovalent dimer of single-chain Fv (scFv) fragment comprised of two chains expressed separately, each of which consists of a VH from one antibody and a VL from another antibody. https://www.creative-biolabs.com/bsab/category/diabody-29.htm
TandAb (Tandem diabody) is a type of bispecific antibody fragments. TandAb is a tetravalent bispecific molecule, 2+2 antigen-binding valency, consisting solely of Fv domains. TandAb is expressed as a monomeric subunit (single chain Diabody, scDb) with four variable domains from two parental antibodies. In the subunit, the linkers are too short to form intra-chain pairing, so the 2 polypeptides dimerize in a head-to-tail fashion. TandAbs have been studied as BiTEs (bispecific T cell engagers) or BiKEs (bispecific NK engagers) in tumor immunotherapy. https://www.creative-biolabs.com/bsab/category/tandab-37.htm
Get the right bispecific antibody as per your requirements. Creative Biolabs will perform the most suitable approach to fulfill your demands. Our team successfully produced all three types of bispecific antibodies using well-established methods.
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