Cytochrome P450 Enzymes Drug Interactions PowerPoint PPT Presentations

Cytochrome P450 enzyme inducers and inhibitors are dealt in this presentation.

Pharmacokinetic drug interactions are dealt in this presentation.

Assistant Professor of Internal Medicine. Division of Infectious Disease and International Medicine. University of ... SSRIs - Prozac, Paxil, Zoloft, Lexapro ...

Sulfonylureas may interact with Azole antifungals (Fluconazole), Fibrates (Gemfibrozil), Sulphonamides (Trimethoprim), Macrolide antibiotics (Erythromycin), Rifampin, Bosentan, Antacids, Alpha glucosidase inhibitors, Bile-acid binding resins (Colestyramine, colestipol, and colesevelam), ACE inhibitors, Allopurinol and Alcohol.

If a patient is currently on oral contraceptives, what mood stabilizer can be ... Patient is on cyclobenzaprine and is depressed. What drug will increase its levels? ...

Nalbuphine ,fentanyl &,tramadol. Interactions. Naloxon(Narcan) ... decreases effect of tramadol (Systemic ,Spinal & Epidural) 100 times as potent as morphine. ...

Safety of Herb - Drug combination treatments

AMDA and ASCP summarised top 10 danferous drug interactions involving Warfarin, ACE inhibitors, Digoxin or Theophylline with other drugs

This speaker has the following significant financial ... This set has been peer-reviewed to ensure that there are ... Tadalafil (Cialis ): max dose 10 ...

After one week , the patient accidently but lightly bumped her arm on the side ... After investigation ,the physcian discovered that this herbal coktail ...

drug interactions in mice. W.M. Tom. Department of Pharmacology ... of anesthesia ... today for general anesthesia. Drug abuse problems ! phenobarbitone ...

Introduction to Drug Interactions Al Patterson, PharmD Drug Drug Interaction phenomena that occurs when the effects (pharmacodynamics) or pharmacokinetics ...

This presentation is dealt with the general introduction of Drug interactions such as factors affecting DIs, Cosequences, Types and Mechanisms of DIs.

Into the tubule. Blood Brain Barrier. Out of the brain ... with active transport of organic acids and bases across the renal tubule ...

the Patient with Aspergillosis Russell E. Lewis, Pharm.D., FCCP Associate Professor University of Houston College of Pharmacy/ The University of Texas M.D. Anderson ...

Pharmacokinetic: Elimination ... benzodiazeines- diazepam, midazolam; cyclosporine, tacrolimus,; HIV Protease Inhibitors indinavir, ritonavir; chlorpheniramine; ...

and Drug Interactions. Michael Thompson PharmD, BCNSP. Professor of Pharmacy Practice ... Food decreases levels by 77% (not a problem if boosted with ritonavir) ...

The Organic Chemistry of Drug Design and Drug Action Chapter 5 Enzyme Inhibition and Inactivation Enzyme Inhibition and Inactivation Categories of Enzyme Inhibitors ...

The Organic Chemistry of Drug Design and Drug Action Chapter 6 DNA-Interactive Agents DNA-Interactive Agents Cancer Cells Structure-Based Design of Potential Drugs ...

Adequate and effective treatment essential in order to cure ... Miliary/disseminated TB. Pericardial TB. Genito-urinary TB. NICE guidelines. Meningeal/CNS TB ...

Grapefruit 'Juicy' Details on Health Benefits and Drug Interactions ... Some pills become too potent when you drink grapefruit juice. Grapefruit juice and ...

Validation of Model of Cytochrome P450 2D6: An in Silico Tool for Predicting Metabolism and Inhibition Carol A. Kemp, Jack U. Flanagan, Annamaria J. van Eldik, Jean ...

List the major routes of drug administration and elimination. ... Drugs act within the physiological system to alter responses ...

1. in vitro assessment of tipranavir to inhibit cytochrome P450 ... Alprazolam. N. N. N. N. N. N. PGP. CYP3A4. CYP2D6. CYP2C9. CYP2C19. CYP1A2. Substrate. 3 ...

Useful drugs may have no benefit because doses are too small to establish therapy ... Microsomal cytochrome P450 monooxygenase family of enzymes, which oxidize drugs ...

drug clearance mechanisms (renal and hepatic) are limited in newborns ... reduced hepatic blood flow. reduced activities of cytochrome P450 enzymes. gender ...

These enzymes metabolize drugs only because the drugs resemble the natural compound ... SSRI antidepressants) Drug Metabolism - Reduction Azo-reduction: Nitro ...

QM/MM Study of Cytochrome P450 BM3 Catalysis Mechanism and Application in Drug Design ... One-half of potential drugs fail because of ADME/Tox issues ...

Classification of antifungal drugs: Can be classify to six groups. 1- Antibiotics [ Amphotricin B,(AMB), Nystatin, Greiofulvin] 2- Antimetabolities [ 5- Flucytosine,(5-FC), inhibition nucleic acid synthesis] 3- Azoles: a-Imidazoles: Bifonazole, Clotrimazole, Econazole, Ketoconazole, Miconazol. b- Triazoles: Fluconazole, Itraconazole, Voriconazole Inhibition of ergosterol synthesis. 4- Allylamine [Terbinafine, Naftifine ] Inhibition of Lanosterol and Ergosterol synthesis. 5- Echinocandins Inhibit fungal cell wall biosynthesis 6- Miscellaneous Antifungals [Tolnaftant, Undecylenic acid, Benzoic acid, Ciclopirox olamine.]

... family of enzymes Metabolizes a broad range of structurally diverse endogenous and exogenous compounds Structurally related family ... Taxol (cancer drug ...

Antianxiety drugs ILOs By the end of this lecture you will be able to Define different types of anxiety disorders Classify types of drugs used for treatment of anxiety

Title: Antimycobacterial drugs Author: linjun Last modified by: Administrator Created Date: 12/17/2003 2:26:36 PM Document presentation format: (4:3)

MED - For: barbiturate anaesthesia 3-4. benzodiazepines 20 ... sedation, general anaesthesia. enhancement of GABAA receptor function. ketamine ...

Drug Biotransformation Elimination of the drugs Drug Biotransformation Metabolism or biotransformation - complex of processes which provide decreasing of toxicity and ...

Medical Biochemistry Molecular Principles of Structural Organization of Cells 6. ENZYMES Virtually, all reactions in the living organisms are mediated by ...

Monitoring Drug Efficacy & Toxicity - along with drug metabolism Michael E. Hodsdon, MD, PhD Associate Professor Departments of Laboratory Medicine & Pharmacology

ADVERSE DRUG EVENTS G za T. Ter zhalmy, D.D.S., M.A. Professor and Dean Emeritus School of Dental Medicine Case Western ...

... preoperative cytostatic treatment in patients with locally advanced solid tumors; ... used in the treatment of cancer interfere with the production ...

Antianxiety drugs Prof. Hanan H. Hagar Pharmacology Department College of Medicine Tricyclic Antidepressants Doxepin- imipramine act by reducing uptake of 5HT & NA.

4. Describe how drugs are removed from the body. ... definition of prodrug an inactive form of a drug that is converted to active form in the body. ...

Toxicology is the science that deals with the amount of an agent that causes an ... MED - For: barbiturate anaesthesia 3-4. benzodiazepines 20 ...

Faculty of Pharmacy Department of Pharmacology 5th year Pharmacy Students Drug-Drug Interaction Antimicrobial Drugs Antimicrobial Drugs Infectious disease is defined ...

Varying half-life (6-72 hours) ... protein C which is eliminated faster as its half-life is much shorter. ... ten most problematic drug interactions in the US ...

... of anticonvulsant treatment to confirm that drug is within the theraputic level. Non-compliant patients At time of status epilepticus For patients with poly ...

ANTI MYCOBACTERIAL DRUGS Dr.Saeed Ahmad Department of Pharmacology King Saud University DAPSONE & OTHER SULFONES Erythema nodosum leprosum Develops during dapsone ...

Discuss storage and availability in country. Discuss pros and cons and availability of generic drugs in country ... A possible side effect is Fanconi syndrome ...

Tonic clonic: hypoxia could develop if muscle contraction is lengthened. ... Drug of choice for tonic-clonic & parital seizures. Low side effects ...

Lesson 9 Drug Elimination Process 9 1. Drug Elimination Elimination( ) = Metabolism( ...

Drug Metabolism and Pharmacogenetics Brendan Stamper University of Washington Dept. of Medicinal Chemistry * * * * * Figure 2. Two types of variability in drug action.

Pharmacology of Antiepileptic Drugs Melanie K. Tallent, Ph.D. tallent@drexel.edu ...

Pharmacology of Antiepileptic Drugs Melanie K. Tallent, Ph.D. tallent@drexel.edu Basic Mechanisms Underlying Seizures and Epilepsy Seizure: the clinical manifestation ...

Metabolic Changes of Drugs Books: 1. Wilson and Gisvold s Textbook of Organic Medicinal and Pharmaceutical Chemistry 11th ed. Lippincott, Williams & Wilkins ed.

Modern Methods in Drug Discovery Aims of this course: comprehensive knowledge about all processes in the drug discovery pipeline in particular in silico methods of ...

Modern Methods in Drug Discovery Aims of this course: comprehensive knowledge about all processes in the drug discovery pipeline in particular in silico methods of ...

Drugs used in anxiety and panic disorders Prof. Hanan Hagar Pharmacology Unit College of Medicine Tricyclic Antidepressants Doxepin- imipramine act by reducing uptake ...

PHARMACOLOGY 1391 Studies the effects of drugs and how they exert their effects. acetylsalicylic acid (ASA) reduce inflammation, pain and fever inhibit the action of ...