Cardiotoxicity PowerPoint PPT Presentations

Cocaine (benzoylmethylecgonine) is derived from the leaves of Erythroxylon coca, ... International Journal of Cardiology, 1994. Pharmacology ...

... Focal Necrosis, Contraction Band Necrosis. Coronary Spasm. Direct ... Recommendations of the American Heart Association for the treatment of Cocaine ...

Initially, a nanoparticle emulsion was synthesized as described in a previous ... 'We hypothesize that smaller emulsion particles (ie: nanoemulsions) will even ...

Hortobagyi1989 52 adult mamma epi. median 520. Lipshultz 2002 145 child leukemia doxo ... median 360. Zalupski 1991 240 adult mamma doxo. median 240 ...

... Extravasation Myelosuppression Cardiotoxicity Second Cancer Emesis Mucositis ... Slide 6 Potential mechanisms of Glivec ...

... ( Hashimotos thyroiditis) ... it may provoke cardiotoxicity I.V hydrocortisone may be used in case of adrenal and pituitary ... presentation format:

Acidosis. Hyperglycemia. Increase the cardiotoxicity ... Metabolic acidosis. Hypothermia. Slows the metabolism of citrate. Exacerbate hypocalcemic status ...

Increased 8OHdG w/ increase arachidonic acid intake & higher BMI ... Alpha-lipoic acid neurotoxicity. Coenzyme Q-10 - cardiotoxicity. Secondary prevention ...

In Vitro Toxicity is a scientific method of testing toxic chemical substances on cultured bacteria or mammalian cells. Drug toxicity is the major reason for withdrawal of drugs from the market which causes a company huge amount of financial costs and losses. Hepatotoxicity and cardiotoxicity are the most recurring drug toxicity. In Vitro toxicity involve assays of cultured bacteria or mammalian cells.

Study in Japanese Society of Anesthesiologist Certified Training Hospital. 4,291,925 anesthetics ... Blocking SNS or PNS efferent activity ...

Narine Sarvazyan, Ph.D. Pharmacology and Physiology Dept, The George Washington University Medical Center ... Contracting cells of cardiac lineage are ...

Her past medical history is significant for ovarian carcinoma s/p hysterectomy ... S. Jeffers et alia, Pegylated liposomal doxorubicin (doxil): reduced clinical ...

In-vitro Toxicity Testing in Drug Development

To provide information on the cardiac risks of chemotherapy and the various ... Long-tern cardiac toxicity for survivors of childhood leukemia ...

Rofecoxib Promotes F2-Isoprostane and Ox-LDL through a non-Enzymatic Pathway ... Ox-LDL. Plasma Antioxidant Capacity. CV Risk. Reactive Metabolites. Altered ...

Eligibility Criteria. Unilateral or bilateral untreated breast cancer. Tumor 2 cm (palpation) or 1 cm (US) Given indication for chemotherapy, e.g.: cT3 or cT4 (incl. ...

Prolonged half life (55 hrs vs 0.4 - 2 hrs) Three fold greater AUC ... Cholesterol, egg PC. Doxorubicin. TLC-99 (Myocet) Avoids MPS ...

Lipid Rescue Treatment for Local Anesthetic-Induced Cardiac Arrest Current Data 20 out of 10,000 peripheral nerve blocks 4 out of 10,000 epidural block Result in ...

Adapted from Crist et al, J Clin Oncol June 2001. Doxorubicin ... GIST 'Criteria' for Pediatric Phase 1 Study. Availability of new agent for pediatric studies ...

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for breast cancer results in mild subclinical myocardial damage ... and an increase in QTc, which may indicate a long-term risk of CHF. ...

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Clinical Toxicology Case Presentation By Dr. Kevin Go,UCH.

Cancer Survivorship in Primary Care Arlene O Rourke N.P.

Cardiomyopathy Dr.mirdamadi Cardiologist, fellowship of echocardiograpy Apical HCM Apical hypertrophy Giant negative T wave on the ECG Spade shaped LV cavity ...

III' Antitumor Antibiotics

Fluorine (F2) Hydrogen Fluoride (HF) Fluorine (F2) Hydrogen Fluoride (HF) Fluorine - Overview Hydrogen Fluoride - Overview Toxicity Pulmonary irritant agent Severe ...

Internal iliac plexi. Parasympathetic nerves. S2 S4. Cervical ganglion of Frankenhauser ... 3 : posterior superior iliac spine. Intravenous analgesia. Morphine ...

Serotonin produced from tryptophan in nerve terminals. In CNS, serotonergic neurons found ... Impairs reuptake cocaine, ecstasy, SSRIs, SNRI,TCA, St John's Wort ...

brine/oil ratio. surfactant/oil ratio. M Wt. of surfactant. Manipulating ... Surfactant formulation- surfactant, alcohol and brine with or without added oil. ...

hypoglycemia due to the usual dose of insulin in the diabetic patient after ... preexisting heart disease, hypertension, bolus injection rather than a prolonged ...

Nutritional Supplements That Support Cancer Chemotherapy Leo Galland, M.D., F.A.C.P. Foundation for Integrated Medicine General Overview About 1000 drugs and fixed ...

Evaluation of cardiac toxicity related to capecitabine chemotherapy: single centre audit of local practice. Coote J1., McPartlin A2., Lee K1., Misra V1.

Prior / concomitant RT. Age. Previous cardiac disease. Hypertension. Other drugs ... Switching from concomitant to sequential is a pharmacologically sound option to ...

Gilles HANTON, BVSc, DVM, DABT, ERT GH Toxconsulting Brussels, Belgium

Anticancer Agents By: Cristina Sanders * * * * * * * * * * * * * * * * * * * * What is cancer? Cancer is a group of diseases that are characterized by the loss of ...

Has been used in oncologic practice since the late 1960s. ... sarcoma, and soft-tissue sarcomas; and Hodgkin's and non-Hodgkin's lymphomas. ...

Gillian Bone, Physiotherapy. Raymond Buncic, Neuroophthalmology. Peter Anderson, Neuropsychology. Lois Peltz, Psychiatry. Arlette Lefebvre, Psychiatry ...

Breast Cancer: Contemporary Issues, Survivorship, and the . Primary Physician. ... Tamoxifen for ER+ (5 years) Hot flashes, uterine Ca (1/2000 overall, ...

withdrawal symptoms following discontinuation of treatment with benzodiazepines, ... the development of anthracycline-induced congestive heart failure is mainly due ...

Title: Slide 1 Author: David Haen Last modified by: Brian Created Date: 9/30/2004 7:32:02 PM Document presentation format: (4:3) Company

Other drugs e.g. alcohol, caffeine. Unresolved outside problems. ... Lithium, carbamazepine. Mixtures i.e. SSRI and TCA. Dangerous need expert supervision ...

Cohort study. consecutive patients admitted with antidepressant poisoning ... Time to presentation. Clinical Toxicology & Pharmacology, Newcastle Mater ...

Adrenergic blockade critical success factors for stopping disease progression ... Abnormal contractile function. Myocyte apoptosis. Norepinephrine. a-adrenoreceptor ...

Advisory Committee Role in Facilitating FDA Scientific ... Steer collaborative projects. Convene workshops, symposia. Facilitate reporting & recommendations ...

Cardiac Glycosides and Therapy of Congestive Heart Failure Philip Marcus, MD MPH Pathophysiology of Congestive Heart Failure Inability of the heart to pump blood in ...

Roch H et al J Clin Oncol 2006. PACS-01: DFS in different subgroups (Forest plot analysis) ... Roch H et al J Clin Oncol 2006. ECTO Study. Gianni L, et al, ...

... Light micrograph of normal cardiac myocyte ... start of CT 25 patients received placebo Duration 6 months during CT Primary end point Systolic function RCT: ...

in Primary Care Arlene O Rourke N.P. History of the Development of Cancer Survivorship 1985 Fitzhugh Mullen first describes Cancer survivorship 1986-NCCS 1996-NCI ...

SFRBM Lifetime Achievement Award Lecture. Twelfth Annual ... FAD. NADP NADPH. NADPH OXIDASE ACTIVITY. NOS ACTIVITY. H2O2. O2 - O2. ONOO- Adr. Adr - BH4 ...

Quimioter picos y cardiotoxicidad

Canine. 660 nM. 69.3 nM. ND. Mouse. IC90. IC70. IC50. Normalized Values ... Canine. 2640. 760. 83. Mouse. IC90. IC75. IC50. Normalized Values. CFU-GM ...

Factors associated with TNS. Lidocaine use, outpatient status, ... Not associated with TNS. Bupivacaine, age, sex, use of pencil-point needles ... adjuvant ...

You won't give me it because of the cost. I'm going to ... Roche. How does it work? Antibody antigen response. Binds to antigen on certain cancer cells ...

Bupivacaine & prilocaine contain chiral carbon Both have R ... Local Anesthetic Pharmacology * Mechanism of action Ester type local anesthetics are split in ...