Kearns-Sayre Syndrome

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Kearns-Sayre Syndrome

• By Tommy Antony

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Mitochondrial DNA

• Circular DNA
• Encodes for several RNAs and Proteins
• Mitochondria produces energy for the body

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What Is Kearns-Sayre Syndrome

• mitochondrial encephalomyopathies
• Sporadic Mutations
• Heteroplasmy occurs

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Diagnosis

• Eye muscle paralysis
• Pigment Accumulation
• Heart Disease
• Testing

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Symptoms

• Usually occur before age 20
• Other symptoms include, skeletal muscle weakness,
  short stature, hearing loss and deafness, ataxia
  impaired cognitive function and diabetes.
• Pearson Syndrome

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Treatment

• No cure
• Cardiac treatments
• Coenzyme Q10

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Reference

• "Kearns Sayre Syndrome." 17 Feb. 2004. 19 Mar.
  2006 lthttp//www.medterms.com/script/main/art.asp?
  articlekey30811gt.
• McKusick, Victor A., comp. 24 Sept. 1992. John
  Hopkins U. 19 Mar. 2006 lt/www.ncbi.nlm.nih.gov/ent
  rez/dispomim.cgi?id530000gt.
• "Ninds Kearns-Sayre Syndrome Information Page."
  24 Jan. 2006. National Institute of Neurological
  Disorders and Stroke. 19 Mar. 2006
  lthttp//www.ninds.nih.gov/disorders/kearns_sayre/k
  earns_sayre.htmgt.
• Pasternak, Jack J. 2nd ed. Hoboken John Wiley
  Son, Inc, 2005. 358-359.
• Posner, Ewa. "Kearns-Sayre Syndrome." (2005). 19
  Mar. 2006 lthttp//www.emedicine.com/ped/topic2763.
  htmsectionauthor_informationgt.