Belmedpreparaty RUE

1
Belmedpreparaty RUE
TO THE 21th CENTURY WITH THE IDEAL HEALTH

• We are with you since 1929

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The History
Belmedpreparaty RUE
TO THE 21th CENTURY WITH THE IDEAL HEALTH

• Belmedpreparaty is the largest pharmaceutical
  enterprise in the Republic of Belarus being the
  founder of the pharmaceutical industry in the
  country.
• Founded in 1929 as a pharmaceutical factory for
  manufacturing simplest drugs nowadays
  Belmedpreparaty occupies a merited place among
  the other similar Belarus enterprises, providing
  the market with modern highly efficient original
  drugs and import substitutes required by the
  republican health service and competitive at the
  foreign pharmaceutical markets.

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The Strategy
BelmedpreparatyRUE
TO THE 21th CENTURY WITH THE IDEAL HEALTH

• Marketing strategy of the enterprise is
• directed to increase sales at domestic
• market and also to expand the share of
• markets.
• The increase in sales volumes is reached
• not only by the expansion of sales regions
• and attraction of a greater number of
• distributors, but also by updating the drug
• list, which will conform to the quality
• According with the requirements of GMP
• standards and adequate drug promotion at
• the market.

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Our Products
BelmedpreparatyRUE
TO THE 21th CENTURY WITH THE IDEAL HEALTH

• The basic principle of policy of the
• Enterprise is the maintenance of the
• population with accessible at the price of
• and qualitative medical products.
• According to this principle the basic
• directions of the development the factory
• has selected is production of generics, and
• also increasing he number of the original
• preparations.

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The specter of products
BelmedpreparatyRUE
TO THE 21th CENTURY WITH THE IDEAL HEALTH

• RUE Belmedpraparaty is the producer of
  more than 300 medicines which belong to 24
  pharmacotherapeutical groups
• Anticancer medicines,
• Blood substitutes,
• Antiviral agents,
• Biostimulants, immunocorrectors, adaptogens
• Metabolics
• Hormonal medicines
• Antibiotics
• Neurotropic medicines
• Drugs for respiratory system treatment
• Drugs for eyes pathology treatment
• Drugs for gastrointestinal tract pathology
  treatment
• Dermatotropic medicines
• Hematotropics
• Drugs for treatment of diseases of cardiovascular
  system
• Detoxicants

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Certification
BelmedpreparatyRUE
TO THE 21th CENTURY WITH THE IDEAL HEALTH
For realizing the Quality State Program the ISO
9001-2001 quality management system was applied
in February 2004. The Program of implantation of
GMP principles for the step by step has been
worked up for 2004-2010. The enterprise has been
certified for the liquid injection drugs in
bottles and vials manufacture as well as for the
Streptokinase for injections production in
accordance with BST ISO 9001-2001.
The production of liquid sterile drugs in bottles
and vials has been certified in accordance with
the requirements of BST 1435-2004 Production of
medical preparations. Good Manufacture Practice.

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BelmedpreparatyRUE
TO THE 21th CENTURY WITH THE IDEAL HEALTH

• This Certificate attests
• the conformity of the
• producing liquid sterile
• medicinal bottled 10 ml
• and ampouled 2ml and
• 5ml drugs
• with the requirements of
• GMP

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Re-equipping
BelmedpreparatyRUE
TO THE 21th CENTURY WITH THE IDEAL HEALTH
Completion of the technical re-equipping and
certification of the tablets and capsules
production in accordance with the GMP
requirements will allow to increase the share of
products corresponding to international
pharmaceutical standards up to 70. A work on
reconstructing the manufacture of antineoplastics
in the ready form of lyophilized powders and
solutions for injections was begun. Scale
reconstructing and technical re-equipping of the
manufacture of drugs in the form of lyophilized
powders, eye drops, ointments are planned.
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The production line
BelmedpreparatyRUE
TO THE 21th CENTURY WITH THE IDEAL HEALTH
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The Insulins
BelmedpreparatyRUE
TO THE 21th CENTURY WITH THE IDEAL HEALTH

• Medicinal forms, which content pork insulin 100
  miu are released since 2000 and corresponded to
  the requirements of ??, ?ur ?h
• Monosuinsulin MC solution 100 units/ml 10ml
• Insulin-semilong SMC suspension 100 units/ml
  10ml
• Insulin-long SMC suspension 100 units/ml 10ml

• At the last years the preparations based on the
  recombinant insulin are used broadly for
  treatment of the diabetes, as well as at disease
  requiring the insulinotherapy
• Monoinsulinum HR solution 100 IU/ml 10ml
• Protamin-insulin HS suspension 100 IU/ml 10ml

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The Insulins
BelmedpreparatyRUE
TO THE 21th CENTURY WITH THE IDEAL HEALTH
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The Insulins (Human)
BelmedpreparatyRUE
TO THE 21th CENTURY WITH THE IDEAL HEALTH
Protamin-insulin HS suspension for injections 100
IU/ml
Monoinsulinum HR, solution for injections 100
IU/ml
Composition Genetically engineered insulin - 100
IU, protamine sulphate - 0,35 mg,
twice-substituted 2-aqueous sodium phosphate -
1,96 mg, phenol -0,65 mg, metacresol - 1,5 mg,
glycerin - 16 mg, water for injections up to 1
ml. Pharmacological action On subcutaneous
administration (in the subcutaneous fatty tissue)
protamin insulin HS starts to act within 1,5
hours and has a maximal effect between 4th and
12th hour the duration of action is up to 24
hours. Because of prolonged action protamin
insulin HS is frequently prescribed in
combination with insulin medications of short
duration.
Formulation Genetically engineered human insulin
100 IU, metacresol 3.0 mg, glycerin 16 mg,
water for injections up to 1 ml. Pharmacological
Action After subcutaneous introduction (in
subcutaneous fatty tissue) Monoinsulin HR acts
rapidly (within half an hour) and has a maximum
effect between the 1st and the 3d hours duration
of action is approximately 8 hours. Due to
short-term action Monoinsulin HR is often
prescribed in a combination with insulin drugs of
more prolonged action.
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Ovomine
BelmedpreparatyRUE
TO THE 21th CENTURY WITH THE IDEAL HEALTH
Pharmacodynamics The medication agent is
ovomucouid, glycoprotein of duck eggs. It has a
proteolysis inhibitory action, forwards the
removal of pathological hyperactivity of
proteinase systems of organs and tissues. The
medication has a multipartial antiproteinase
activity mainly towards serine proteinase
tripsin, alpha-chemotripsin, leukocytic and
pancreatic elastase, leukocytic catepsins G, as
well as towards some bacterial proteinases. One
ovomucoiud molecule is able to interact with a
alpha-chemotripsin molecule and two tripsin
molecules inhibing their activity up to 95. The
medication stimulates a selective proteolytic
enzyme inhibition in the blood and plasma, leads
to the organism detoxication in the pathological
condition accompanying by proteolysis activation
and enzymatic intoxication, as well as prevents
irreversible destruction of protein substances in
the biological fluids. The medication neutralizes
activated proteinases without changing the
inhibitor concentration of these enzymes. The
consequence of the balance in the system
proteinase-inhibitors reached by ovomine
administration is stabilization of the main
parameters of the systemic hemodynamics,
normalization of vascular penetration, reduction
in generation of cardiotropic, vasotropic and
other biologically active peptides. Intra-articula
r administration of the preparation leads to
neutralization of excessive level of proteolytic
lysosomal enzymes (inflammation mediators) in the
synovial fluid and arresting of the local
inflammatory reaction in the joint.
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Emoxipine
BelmedpreparatyRUE
TO THE 21th CENTURY WITH THE IDEAL HEALTH
Emoxipine reduces permeability of vascular wall,
viscosity and coagulability of blood,
agglutination ability of erythrocytes. Increases
process of fibrinolysis. Improves
microcirculation. The preparation protects eye
retina from damaging action of light of high
intensity, promotes resorption of intraocular
hemorrhages.
Emoxipine reduces signs of cerebral
hemodysfunction. It increases brain resistance to
hypoxia and ischemia. At disturbances of cerebral
circulation (ischemic and hemorrhagic) it
promotes correction of vegetative dysfunctions,
relieves restoration of brain integrative
activity, improves mnemonics functions. The
preparation possesses the expressed
cardioprotective action. It dilates coronary
vessels, reduces ischemic damage of myocardium.
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Streptokinaza
BelmedpreparatyRUE
TO THE 21th CENTURY WITH THE IDEAL HEALTH
Streptokinase is an enzyme preparation received
from the culture of ß-hemolytic streptococci from
the C group. The preparation has a fibrinolytic
activity caused by its capability to interact
with the blood plasminogen. The streptokinase and
plasminogen complex has a proteolytic activity
and catalyzes the plasminogen turning into
plasmin. The latter can cause the fibrin lysis in
blood clots, inactivate fibrinogen as well as the
blood coagulaion factors V and VII. The
streptokinase activity is determined by the
preparation capability to lyse the fibrin clot
formed by the fibrinogen and thrombin solutions
mixture under the certain conditions and it is
expressed in the international units (IU).
Streptokinase is used for restoring the
thrombosed blood vessels permeability the
preparation causes the thrombus lysis effecting
them both from the surface and penetrating inside
the thrombus (especially when the thrombus is
fresh).
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Mexibel
BelmedpreparatyRUE
TO THE 21th CENTURY WITH THE IDEAL HEALTH
The preparation improves memory and working
capacity. It has anxiolytic action, eliminates
alert, fear, stress, anxiety, improves the
emotional status. It possesses neuroprotective
action, stimulates restoration -adaptive
processes in brain at craniocerebral trauma. It
promotes acceleration of evolution of
intracerebral, including posttraumatic,
hemorrhages. In structure of complex therapy in
persons suffered from acute disturbance of
cerebral circulation it has beneficial effect on
processes of oxygen mass transfer in brain in
conditions of hypoxia, reducing the maximal rate
of respiration and enlarging a stationary level
of oxygen partial pressure in nervous tissue. It
reduces consequences of reperfusion syndrome at
coronary deficiency.
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Butorphanol sodium tartrate
BelmedpreparatyRUE
WITH PERFECT HEALS IN XXI CENTURY
Butorphanol is opiod analgesic, an
agonist-antagonist of opiod receptors, derivative
of fenantren. Has agonistic action in relation to
opiod receptors of kappa class, and it is mixed
antagonist of ?-opiod receptors. Activates
endogenous antinociceptive system mainly through
kappa-opiod receptors and thus disturb
interneuronic transmission of painful impulses at
various levels of the central nervous system, and
also changes emotional picture of pain,
influencing on the high parts of
brain. Indications Butorphanol is applied as
anesthetizing agent at the expressed painful
syndrome of various origin, in the preoperative,
operational and postoperative periods, pains at
malignant neoplasms, for anesthesia during labors
(at absence of fetal pathology signs in fetus).
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Anticancer drugs
BelmedpreparatyRUE
TO THE 21th CENTURY WITH THE IDEAL HEALTH

• Hydroxycarbamide, capsules 0,25g
• Doxorubicine Hydrohloride, powder for injections
  0,01g
• Leucladine, solution for injections 0,1 ampoules
  2/5 ml, vials 5/10ml
• Mercaptopurin, tablets 0,05g
• Tioguanin, tablets 0,04g
• Cyclophosphan, powder for injections 0,2g
• Cytarabine, lyophilized powder for injections
  0,1g
• Fludarabel, lyophilized powder for injections
  0,05g ampoules

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Hydroxycarbamide
BelmedpreparatyRUE
TO THE 21th CENTURY WITH THE IDEAL HEALTH
Mechanism of antineoplastic activity is
associated with the ability of hydroxycarbamide
to inhibit RNA-phosphate reductase one of the
main enzymes participating in DNA biosynthesis.
The preparation rapidly interferes with DNA
synthesis, not influencing protein and RNA
synthesis, which leads to the cytotoxic
effect. Hydroxycarbamide exhibits specific
antineoplastic effect against quickly
proliferating transformed cells and does not have
pronounced cytotoxic activity against weakly
proliferating or non proliferating normal
cells. Adequate period for the assessment of
antineoplastic efficacy of the preparation is 6
weeks. The reduction of the tumour size or
stopping of the tumor growth is indicative of the
effect of the preparation.
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Anticancer drugs
BelmedpreparatyRUE
TO THE 21th CENTURY WITH THE IDEAL HEALTH
Photolon, lyophilized powder to prepare a
solution for injection. Antineoplastic agent,
photosensitizer for photodynamic therapy.
Leucladin
Photolon
Leucladin, solution for injection. Administration
of medication provides a persistent remission in
patients with hairy-cell leukemia.
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Plasma-substituting and perfusion solutions
BelmedpreparatyRUE
TO THE 21th CENTURY WITH THE IDEAL HEALTH

• Hemodez, solutions for infusions vials 200, 400ml
• Glucose, solution for injections 05/10/20/40
  vials 200/400ml
• Ladpulin, solutions for infusions vials 200,
  400ml
• Microdez, solutions for infusions vials 200,
  400ml
• Neogemodez, solutions for infusions vials 50,
  100, 200, 400ml
• Neorondex, solutions for infusions vials 200,
  400ml
• Poliglucine, solutions for infusions vials
  100,200,400ml
• Poliglusol solutions for infusions vials
  100,200,400ml
• Rheoglumane solutions for infusions vials
  100,200,400ml
• Rheopoliglucine (Decstrose) solutions for
  infusions vials 200,400ml
• Rheopoliglucine with glucose (Decstrose)
  solutions for infusions vials 200,400ml
• Rondferrine solutions for infusions vials 400ml

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Solutio pro infusia Microdesum
BelmedpreparatyRUE
TO THE 21th CENTURY WITH THE IDEAL HEALTH
The preparation possesses disintoxication
properties stipulated by the ability of binding
circulating in blood toxins and degradation
metabolic products and of fast excreting them
from organism. It increases suspension stability
of blood, alleviates its viscosity
characteristics, possesses antiaggregant and
desaggregation action onto regular elements,
promotes for elimination of peripheral stasis and
erythrocyte aggregation so leading to activation
of microcirculation and increase of tissual blood
flow. It blocks development of disseminated
intravascular clotting, normalizes lipid
peroxidation processes. It stabilizes systemic
hemodynamics causes active attraction of tissual
liquid to systemic blood flow and restraining it
in the bloodstream.
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Neorondex (solution for infusions)
BelmedpreparatyRUE
TO THE 21th CENTURY WITH THE IDEAL HEALTH
Neorondex is a blood substitute of apparent
hemodynamic action. It is a high-performance drug
with respect to elimination of systemic
hemodynamics, adjustment of volume of circulating
blood and plasma, mean blood pressure, stroke and
minute blood volume, elimination of peripheral
vessels spasm. Introduction of Neorondex
positively manifests itself in normalization of
basic quotients of acid-base balance and gas
composition of blood. The preparation increases
suspension resistance of blood, reduces its
viscosity characteristics, has an apparent
antiadhesive and antiaggregatory influence to
thrombocytes, promoting to elimination of
peripheral stasis and erythrocyte aggregation, so
resulting in improvement of rheological
properties of blood, activation of
microcirculation and increase of tissual blood
flow. Infusions of Neorondex block the
development of disseminated intravascular
coagulation (DIC).
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Rondferrin(solution for infusion)
BelmedpreparatyRUE
TO THE 21th CENTURY WITH THE IDEAL HEALTH
The basic special-purpose designation of
rondofferin is the elimination of infringements
macro- and microhemodynamics, stabilization of
rheological properties of blood and stimulation
of hemopoietic erythroid functions of a bone
brain. Rondferrin blood substitute with
expressed multifunctional action, possessing
alongside with hemodynamic effect ability to
stimulate haemopoiesis. Is the proof-reader of
infringements hemodynamic system, volume of
circulating blood and plasma, average arterial
pressure, propulsion abilities of a myocardium.
Rondferrin introduction is leads to liquidation
of a spasm of peripheral vessels, normalizes
suspension stability of blood, stabilizes it
frictional and hemorheological characteristics,
renders antiaggregantal influence on platelets
and erythrocytes, promotes elimination peripheral
stasises therefore improves nutritious blood
circulation. The preparation has positive
influence on oxygen-transport function and gas
structure of blood, and on ability to show buffer
properties and to normalize the parameters of
acid-alkaline balance surpasses blood substitute
solutions on the basis of acid-hydrolized
dextran. Rondferrin infusions has direct
hemostimulating antianemic actions, promoting
activation of erythropoietic function of a bone
brain and normalization and maintenance in blood
erythrocytes and hemoglobin.
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Rheopolyglucin(solution for infusion)
BelmedpreparatyRUE
TO THE 21th CENTURY WITH THE IDEAL HEALTH
Rheopolyglucin is colloid glucose polymer
solution 10 (dextran) (?6?10?5) with molecular
mass 3000040000. It is used as
plasma-substituting antichock preparation of
hemodynamic action. It contributes to increasing
of the volume of plasma almost twice in
comparison with the volume of the administered
preparation, as each gram of glucose polymer with
molecular mass 3000040000 induces the
transportation of 2025 ml of liquid from the
tissues into the blood bed. Due to high oncotic
pressure rheopolyglucin slowly penetrates through
the vase wall and circulates for long in the
vascular bed normalizing hemodynamics thanks to
the concentration gradient from the tissues into
vessels. As a result, blood pressure increases
and keeps for long at a high level, and tissue
edema reduces.
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Antibiotics
BelmedpreparatyRUE
TO THE 21th CENTURY WITH THE IDEAL HEALTH

• Azytromicin, capsules 0,25g
• Amoxicillin, capsules 0,25g
• Ampicillin Trihydrate, tablets 0,25g
• Ampicillin-Oxacillin, capsules0,25g
• Gentamicin Sulphate, solution for injection 4
  1/2 ml ampoules
• Glurifor, 0,1g granular powder for suspension
• Doxycycline Hydrohloride, capsules0,05g and 0,1g
• Levomycetin, capsules 0,25g
• Lincomycin Hydrohloride, capsules 0,25g
• Lincomycin Hydrohloride, solution for injection
  30 1/2 ml ampoules
• Rifampicin, lyophilized powder for injections
  0,15g ampoules
• Pifampicin, capsules 0,15g
• Tetracycline, tablets 0,1g
• Tetracycline, capsules 0,25g
• Cefazolin Sodium, powder for injections 0,5/1,0g
• Cefalexin, capsules 0,25g
• Cefotaxim, powder for injections 0,5/1g

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Our addresses
BelmedpreparatyRUE
TO THE 21th CENTURY WITH THE IDEAL HEALTH

• Belmedpreparaty RUE
• Fabritsius str., 30,
• Minsk 220007, Republic of Belarus
• Tel. [phone]
• Fax [phone]
• E-mail medic_at_belmedpreparaty.com
• www.belmedpreparaty.com
• Commercial centre
• Tel. [phone], 44, 47
• Fax [phone], 43
• E-mail southeast1_at_belmedpreparaty.com