Diabetic Retinopathy Clinical Research Network (DRCR.net)

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Diabetic Retinopathy Clinical Research Network
(DRCR.net)
Dedicated to multicenter clinical research of
diabetic retinopathy, macular edema and
associated disorders.
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DRCR Network Overview

• Objective
• Develop and operate a collaborative network to
  facilitate multicenter clinical research on
  diabetic retinopathy, diabetic macular edema and
  associated conditions.

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• There have been 2716 subjects recruited for
  DRCR.net studies since the networks inception
• 437 investigators have been certified for at
  least one protocol.  

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DRCR Network Overview

• Funding
• National Eye Institute (NEI)
• Sponsored cooperative agreement initiated
  September 2002 initially through December 31,
  2008
• Competitive renewal request every 5 years
• Renewed from 2009-2013
• Industry collaborations
• Foundations (e.g. JDRF)
• Unrestricted gifts

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Priority Initiatives

• Involvement of community-based practices, as well
  as academic centers
• Collaborate with industry to facilitate
  investigations and pursue opportunities otherwise
  not possible and to do so in a manner consistent
  with the Networks dedication to academic
  integrity and optimal clinical trial performance

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Network Organization

• Coordinating Center
• Roy Beck, M.D., Ph.D. (Executive Director)
• Adam Glassman, M.S. (Assistant Director)
• Network Chair
• Neil M. Bressler, M.D. (current)
• Lloyd Paul Aiello, M.D., Ph.D. (inaugural past
  chair)
• Network Vice-Chairs
• Susan Bressler, M.D.
• Scott Friedman, M.D.
• Ingrid Scott, M.D.
• NEI
• Donald F. Everett, M.A.

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Network Enrollment as of 9-31-09
Protocol of Subjects
A A Pilot Study of Laser Photocoagulation for DME 319
B A Randomized Trial Comparing Intravitreal Triamcinolone Acetonide and Laser Photocoagulation for DME 693
C Temporal Variation in Optical Coherence Tomography Measurements of Retinal Thickening in DME 107
D Evaluation of Vitrectomy for DME 241
E A Pilot Study of Peribulbar Triamcinolone Acetonide for DME 113
F An Observational Study of the Development of DME Following Scatter Laser Photocoagulation 155
G Subclinical Diabetic Macular Edema Study 613
H Phase 2 Randomized Trial of Bevacizumab for DME 121
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Network Enrollment as of 9-31-09
Protocol of Subjects
I Intravitreal Ranibizumab or Triamcinolone Acetonide in Combination with Laser Photocoagulation for DME 691
J Intravitreal Ranibizumab or Triamcinolone Acetonide as Adjunctive Treatment to Panretinal Photocoagulation for Proliferative Diabetic Retinopathy 333
K The Course of Response to Focal Photocoagulation for DME 128
Currently Recruiting Currently Recruiting
LEvaluation of Visual Acuity Measurements in Eyes with Diabetic Macular Edema 209
O Comparison of Time Domain OCT and Spectral Domain OCT Retinal Thickness Measurement in Diabetic Macular Edema 24
P Pilot study in individuals with center-involved diabetic macular edema undergoing cataract surgery.
Q An observational study in individuals with diabetic retinopathy without center-involved diabetic macular edema undergoing cataract surgery.
DRCR Network Study Subject Total 3,747
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For information about

• Becoming a DRCR network investigator
• Proposing collaborative clinical trial
  opportunities
• A complete listing of DRCR publications
• Or for other information
• E-mail drcrnet_at_jaeb.org
• Or visit or our website www.drcr.net