Development of a Wearable, Wireless, NIR* Imaging Device

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Development of a Wearable, Wireless, NIR Imaging
Device
Near InfraRed

• Rowan University Biosensors Lab
• Linda M. Head PhD, Faculty Director
• Rane Pierson BSECE, MS Student
• Undergraduate Students
• Jessica Donovan, Andrew Flanyak, Michael McDonald

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OUTLINE

1. Uses of fNIR
2. Our goals
3. Progress to date
4. Future work
5. Acknowledgements
6. References

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APPLICATIONS OF NIR SENSING IMAGING TECHNIQUES

• Absorption of radiation by Hb and HbO2 exceeds
  absorption by H2O at NIR wavelengths. 1
• Medical applications for near-infrared have
  proliferated into areas of blood analyte
  monitoring and imaging of materials including
  tissue. 2,3
• Specific applications include
• Oximetry measurement of O2 levels in the blood
  (e.g. pulse oximetry) 4
• Non-invasive assessment of brain function 5
• In-vivo muscle metabolism measurement 6

Figure 1 Hb and HbO2 absorption spectra 1
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GOALS FOR ROWAN NIR IMAGING PROJECT
Fully modular and programmable NIR sensor.

• Integrated electronics
• Custom package
• Reconfigurable FPGA-based control and data
  processing
• Wireless portability

Figure 2 Modular Concept Drawing
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STATE OF THE PROJECT INTEGRATED ELECTRONICS

• Prototype component-based version of control
  system completed.
• ? designation
• Sampling rate
• Noise suppression
• Data storage transmission
• Spartan3 development board prototype.

Figure 3 Component-Based Board layout
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STATE OF THE PROJECTSENSOR

• NIR LED with 4 programmable settings
• dark 730 nm 805 nm 850 nm
• OPT101 Photodiode detector
• Customizable package with embedded flexible
  circuit
• http//www.youtube.com/watch?vj5SYnL0bh50

Figure 5 Version1, Molded Rubber Sensor Assembly
Figure 4 EPITEX NIR LED Specifications
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STATE OF THE PROJECTWIRELESS SOLUTION

• Goal is a single chip solution that can be
  embedded in the individual sensor modules
• Single unit/multiple sensor custom design
• Multiple unit/multiple sensor modular design
• Wireless network solutions required
• Development board in use for
• design prototypes

Figure 6 Radiotronix RK-Wi232-DTS-R 7
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FUTURE PLANS
Project Planning
Prototype Production
Testing/Verification
Sensor Package
Phantom Production
Funding Proposals
FPGA Solutions
Data Analysis Solution
Conference Presentations
Wireless Network
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ACKNOWLEDGEMENTS

• Initial project conceived in collaboration with
  the Functional Optical Brain Imaging group at
  Drexel University.
• Funding provided by Rowan Deans Research Fund,
  Electrical Computer Engineering program.
• Dr Sachin Shetty for conversations on wireless
  networks.
• Drs. Ramachandran and Tang for allowing
  undergraduates to miss class today!

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REFERENCES

1. http//www.biop.dk/Research/Main_research_tweezers
   .htm
2. http//www.spectroscopynow.com/coi/cda/detail.cda
   id1881typeEducationFeaturechId2page1Refs
3. E. Ciurczak and J. Drennen, Near-Infrared
   Spectroscopy in Pharmaceutical and Medical
   Applications, Marcel-Dekker, Inc. New York, 2002.
4. Yoshiya I, Shimada Y, Tanaka K.
   Spectrophotometric monitoring of arterial oxygen
   in the fingertip. Med Biol Eng Comput
   19801827-32
5. Wolf M, et al. Progress of near infrared
   spectroscopy and imaging instrumentation for
   brain and muscle clinical applications. J.
   Biomed. Opt. 2007 12, 062104. Review
6. Yuanqing Lin,a) Gwen Lech, Shoko Nioka, Xavier
   Intes, and Britton Chance, Noninvasive,
   low-noise, fast imaging of blood volume and
   deoxygenation changes in muscles using
   light-emitting diode continuous-wave imager.
   Review of Scientific Instruments, Vol. 73, No. 8,
   August 2002.
7. http//www.radiotronix.com/products/proddb.asp?Pro
   dID12