Addison Disease

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Addison Disease

• Brenda Sengsavath
• CHEM 4700
• Protein Structure Function
• 3.18.15

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What is Addison Disease?

• Addison Disease is when your body produces
  insufficient amount of certain hormones produced
  by your adrenal glands.
• Symptoms
• Muscle weakness and fatigue
• Weight loss and decreased appetite
• Darkening of Skin
• Salt Craving
• Depression
• Body Hair Loss and Sexual Dysfunction in women
• Low Blood Pressure
• Term of Sickness?
• Although the disease is a lifelong condition, but
  there are no long-term implications that
  medication cannot take care of.

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Affects of Addison Disease

• We know that Addison Disease is caused by the
  insufficient steroid hormones, which can also
  damage the bodys immune system.
• In order for the adrenal gland to function, it
  requires cholesterol, which is converted
  biochemically into steroid hormones.
• In biological terms, Addison disease is a rare
  endocrine disease that results from
  underproduction of aldosterone and cortisol
  hormones by the adrenal glands.
• Treatment
• Addison disease is treated by taking medication
  in replacement of needed cortisol depending on
  different individuals.
• Treatment usually involves replacing the hormones
  that the adrenal cortex is no longer
  manufacturing.
• If medications are properly taken, there should
  not be any side effects.

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Addison Disease
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Secondary Motifs and Domains

• There are stable, independently folding formed by
  the segments of the chain with function
  distinguishable from other regions and stabilized
  through the same kind of linkages.
• Sometimes it may contain motifs, sometimes dont.
  
• It does contain some domains referring back to
  the image.
• There are small ligand and surface to bind to
  other proteins.
• In some cases, each domain in a protein is
  encoded by a separate exon.

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References

• Addison T. On the Constitutional and Local
  Effects of Disease of the Supra-renal Capsules.
  London, UK Samuel Highley 1855.
• Alder R. Addison's disease. MagillS Medical
  Guide (Online Edition) serial online. January
  2013Available from Research Starters, Ipswich,
  MA. Accessed April 29, 2014.
• Blackie, Rosmary. Chemist Druggist. 10/13/2012,
  Vol. 278 Issue 6842, p14-18. 3p.
• Huseby ES. Replacement therapy for Addison's
  disease recent developments. Expert Opin
  Investig Drugs. 2008 Apr17(4)497-509. doi
• Micheals, A. Michels, N. Addison disease early
  detection adn treatment principles. April 2014
  Avaliable from http//www.ncbi.nlm.nih.gov/pubmed
  /24695602. Accessed March 18, 2015.
• Lovas, K. Husebye, ES. Replacement therapy in
  Addisons Disease. Feb. 2004. http//www.ncbi.nlm.
  nih.gov/pubmed/14640913. Accessed Marc 18, 2015.
• Napier C. Pearce SH. Current and Emerging
  Therapies for Addisons Diease. June 2014.
  http//www.ncbi.nlm.nih.gov/pubmed/24755997.
  Accessed March 18, 2015.