Cortical structures

1
Cortical structures eg pain,
fear, sights, smells, raised ICP
Benzodiazepines steroids
?GABA
Vomiting centre levomepromazine
Hyoscine Cyclizine
M H1 5-HT2
Vestibular Apparatus Levomepromazine
Cyclizine Hyoscine
Chemoreceptor trigger zone (CTZ) eg drugs,
toxins, biochemical upset Haloperidol Metoclopr
amide Levomepromazine
H1 M
D2 5-HT3 M
Autonomic nervous system (vagus nerve) eg
pharyngeal irritation, gastric/bowel obstruction,
constipation Levomepromazine
Metoclopramide Ondansetron
NV Key Site Cause Antiemetic Highest
receptor affinity top usual first line J Adam
2006
M D2 5-HT3
Receptors