Morinda citrifolia (Noni)

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Morinda citrifolia (Noni)
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Major Component

• Vitamin C, carotene, vitamin A
• Potassium
• Sterol
• flavanoid

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Biological activity

• Antimicrobial
• Antibacterial fruit, root
• Antiviral root
• Anti TB leaves
• Anti helmintic ascaris leaves
• Antitumor activity fruit juice
• Animal cancer
• Leukemia cell line

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Biological activity

• Analgesic activity animal
• Antiinflammatory in vitro cox-2 inhibitor
• Hypotensive activity root
• Immunological fruit
• Inhibit TNF-a, stimulate IFg, IL2
• antioxidant activity

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Clinical Survey

• 67 of cancer(847) significant lessening symptoms
• 72 of overwt lose wt
• 87 of hypertensive has drop in BP
• 90 of chronic pain improve pain
• 80 arthritis improve symptom

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Conclusion

• Animal model or in vitro study
• In human study descriptive, subjective, byass

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The effects of green tea consumption on incidence
of breast cancer and recurrent of breast cancer
a systematic review and meta-analysis

• Aim determine the efficacy of green tea on risk
  of BC development and BC recurrent
• SR and meta-analysis of observational studies 8

Integ Cancer Ther 2005, 4 144-55
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The effects of green tea consumption on incidence
of breast cancer and recurrent of breast cancer
a systematic review and meta-analysis

• Pool relative risk of developing BC in highest
  consumption 0.89 0.71-1.1, p 0.28
• In case control OR 0.44 0.14-1.31. P0.14
• Subgroup analysis of recurrent in stge I, II pool
  RR 0.560.39-0.83 p0.004
• Dose response relationship

Integ Cancer Ther 2005, 4 144-55
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The effects of green tea consumption on incidence
of breast cancer and recurrent of breast cancer
a systematic review and meta-analysis

• Consumption of gt 5 cups of green tea/d shows non
  statistical sig trend towards prevention of BC
• Green tea consumption may possibly help prevent
  breast cancer recurrence in stage I, II

Integ Cancer Ther 2005, 4 144-55
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Conclusion of potential therapeutic application
are currently impossible

• Small number of studies
• lack of clinical trial evidence
• Lack of consistent dose-response relationship
• Potential for interaction with standard care

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Fatty Acid Content in Edible Oil
of total fat
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