QIBA DCE-MRI Technical Committee

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QIBA DCE-MRI Technical Committee

• Jeffrey L. Evelhoch, PhD
• Executive Director, Medical Sciences
• Head, Imaging Sciences

MEDICAL IMAGING CONTINUUM Path Forward for
Advancing the Uses of Medical Imaging in the
Development of New Biopharmaceutical Products 2-3
October 2008 Bethesda, MD
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Members

• M. Buonocore (UC Davis)
• E. Jackson (MDACC)
• G. Karczmar (Chicago)
• D. Barboriak (Duke)
• M. Rosen (Penn)
• M. Schnall (Penn)
• M. Knopp (OSU)

• G. Zahlmann (Siemens)
• D. Purdy (Siemens)
• S. Gupta (GE)
• L. Hilaire (GE)
• G. Slavin (Philips)
• E. Ashton (VirtualScopics)
• A. Schmid (Perceptive)

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Motivation

• Pre-treatment tumor vascularization and/or early
  changes in tumor vascularization in response to
  treatment could identify patients most likely to
  benefit from treatment, particularly
  vascular-directed therapy
• Requires parameters characterizing tumor
  vasculature (Ktrans, IAUC) to be comparable
  between patients, scanners, institutions and over
  time

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Plans

• Define phantom for quantitative DCE-MRI
• Define generic DCE-MRI acquisition protocols
• Plan and conduct phantom study to evaluate
  comparability of protocols across sites/platforms
• Define procedure for routine phantom use
• Develop simulated data set for algorithm testing
• Plan and conduct multi-site test-retest study
  using phantom and generic protocol

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Progress (1)

• Define phantom for quantitative DCE-MRI
• Modified IRAT/ADNI phantom (July 2008)

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Progress (2)

• Define generic DCE-MRI acquisition protocols
• Generic protocols for 1.5 T (July 2008)
• Dynamic
• T1
• Ratio (RF sensitivity correction?)
• Implemented on GE, Philips Siemens scanners
  (September 2008)

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Progress (3)

• Develop simulated data set for algorithm testing
• Dynamic data (August 2008)
• T1 data (October 2008)

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Progress (4)

• Plan and conduct phantom study to evaluate
  protocol comparability across sites/platforms
  (anticipate mid-October 2008 for plan, target
  December 2008 for study completion)
• Define procedure for routine phantom use (target
  January 2009)
• Plan and conduct multi-site test-retest study
  using phantom and generic protocol (target 1Q09
  for plan, 3Q09 for completion)