Ferid Murad

1
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• Ferid Murad
• John S.Dunn?????????
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• ?? lyd0081(DXY)

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Ca
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NOS
NO
CM
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O2
G ???
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ONOO ???????
cGMP
5
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?/???? NADPH ???? FMN,FAD ?????
??? (NMA,NMA)
EDRF/NO ??? (Types-I-?)
EDRF
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NO
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Cyclic GMP
GTP
6
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OH

Ca/CaM BH4 NADPH
Ca/CaM BH4 1/2NADPH
H2N
H2N
N
H2N
O
NH2
HN
HN
HN
N0

H2O
O
O
H2O



H3N
COO-
H3N
H3N
COO-
COO-
L-???
L-???
N-??-L-???
7
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NOS-1 (155kD) ???,???,??1-NOS????????,????????????,??,????,??????.
NOS-2 (125kD) ????,?? II-NOS????,?,???,????,????????
NOS-3 (135kD) ???,?? III-NOS????,??,??????,???
8
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????????? ANF-1
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9
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NO
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????GMP
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10
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11

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• Murad et.al,Adv,Cyclic Nucleotide
  Res.9,145-58,1978.