Presentaci

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Calcium binding proteins
Maria Tereshina Vsevolod Belousov
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Calcium binding protein CaBP2 Results of CD
search by BLAST reveal two Efh domains
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Calcium binding protein CaBP2 Results of CD
search by BLAST reveal two Efh domains, each
consisting of ef-hand motifs
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Stricture of typical ef-hand containing protein,
calmodulin
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Stricture of typical ef-hand containing protein,
calmodulin
4Ca2
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N-terminal domain of calmodulin with bound Ca2
Yellow- key positions in ef-hand, coordinating
Ca2 (usually Asp Glu)
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N-terminal domain of calmodulin with bound Ca2
N-terminal domain of calmodulin with bound Ca2
Yellow- key positions in ef-hand, coordinating
Ca2 (usually Asp Glu)
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Calsequestrin- ER protein with negatively charged
surface that binds Ca2 with low affinity
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Crystal structure of calsequestrin. Red
spacefill- Asp Glu residues
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C2 domains- Ca2-dependent lipid binding folds
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Structure of C2 domain from PKCa
Yellow- Asp residues coordinating Ca2
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Novel Ca2 binding domain in bacterial
collagenases
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Structure of Ca2-binding domain of
collagenase Conformation changes upon Ca2 load
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Structure of Ca2-binding domain of
collagenase Conformation changes upon Ca2 load
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CONCLUSION The diversity of calcium binding
proteins is great!