Chapter 16: The Molecular Basis of Inheritance - PowerPoint PPT Presentation

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Chapter 16: The Molecular Basis of Inheritance

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Title: AP Biology Summer Session Lecture 9 Author. Last modified by: kramon Created Date: 6/19/2004 3:16:17 AM Document presentation format: On-screen Show (4:3) – PowerPoint PPT presentation

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Title: Chapter 16: The Molecular Basis of Inheritance


1
Chapter 16 The Molecular Basis of Inheritance
  • AP Biology
  • Mrs. Ramon

2
What is the genetic material?
  • What was known
  • 1940s ? Chromosomes are carriers of hereditary
    information
  • Chromosomes consist of two substances
  • DNA
  • Proteins
  • The Arguments
  • Protein Camp
  • DNA Camp

3
The Evidence - Griffith
4
More Evidence Avery, McCarty and MacLeod
  • (1944) Purification of various components from
    heat-killed S cells were tested with live R cells
    to test for transformation

5
The Clincher Hershey Chase
  • Genetic material was transferred from a viral
    phage to E. coli during infection
  • Differentially radioactively labeled proteins and
    DNA
  • Labeled DNA was detected

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7
But what does it look like?
  • Structure of DNA
  • Chargaff (1947)
  • Analyzed base composition of DNA from different
    organisms
  • DNA composition is species specific
  • Amounts of the four bases are not equal
  • Ratios of bases vary
  • Chargaffs rules
  • A T
  • C G

8
DNA Structure The Model
  • Rosalind Franklin
  • X-ray image of DNA
  • Watson and Crick
  • Model of DNA
  • Nobel Prize (1962)

9
The Structure of DNA
  • Double helix
  • Antiparallel strands

10
Watson-Crick Base Pairing
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