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Attention Deficit Hyperactivity Disorder

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Attention Deficit Hyperactivity Disorder T. FISHER , H. PRATT and J. AHARON Evoked Potentials Laboratory Technion-Israel Institute of Technology, Haifa, Israel – PowerPoint PPT presentation

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Title: Attention Deficit Hyperactivity Disorder


1
Attention Deficit Hyperactivity Disorder
T. FISHER , H. PRATT and J. AHARON
Evoked Potentials Laboratory Technion-Israel
Institute of Technology, Haifa, Israel
2
The three main symptoms of ADHD
Inattention
Impulsivity
Hyperactivity
3
What are the brain processes associated with the
behavioral impulsivity symptoms?
4
Subjects
  • 14 subjects diagnosed with Attention Deficit and
    Hyperactivity disorder.
  • 14 healthy control subjects matched for age and
    gender
  • Age range 18-30. No co-morbidity of psychiatric,
    neurological or learning disabilities.
  • All subjects were free of medication.

5
Procedure
  • Stimuli 2 binaural tones 1000 Hz (NO-GO)
    2000 Hz (GO) 60 dBnHL for 40 ms.
  • Inter-trial interval 1000 to 2000 ms
  • Task To GO trials press button to stimuli.
    Probability 80.
  • To NO-GO trials inhibit the response.
    Probability 20.

6
GO NO-GO Behavioral Results
7
Electrophysiological resultsgrand average, 28
subjects, midline electrodes
Control subjects
ADHD subjects
P3
P3
N2
N2
P3
P3
N2
N2
P3
P3
N2
N2
8
ADHD vs. CTRL in NO-GO Trials
9

LORETA images of Control ADHD difference
No go , significant voxels, Plt0.05
187- 207 msec
R. Inf. frontal gyrus BA 9, 44,45
Control gt ADHD
10

LORETA images of significant T values
No go , significant voxels, Plt0.05
308-339 Msec
Posterior Cingulate BA 23,29,30,31
Control gt ADHD
stimulus
11
Conclusions
  • The ADHD deficit is in stimulus-related
    processing, not at the perceptual level.
  • ADHD show abnormal activity in brain regions
    attributed to response inhibition and conflict
    monitoring.

12
CTRL N2
N2
ADHD N2
13
CTRL P3
ADHD P3
14
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