Cutaneous Malignant Melanoma

1
Cutaneous Malignant Melanoma
M
F
Fears TR, Tucker MA. J Natl Cancer Inst. 2005,
971789-90
Surveillance, Epidemiology, and End Results
(SEER) Program (www.seer.cancer.gov)
Frances Noonan, EOH,SPHHS drmfpn_at_gwumc.edu
202-994-3970
2
Photobiology of melanoma

• Wavelengths responsible-UVA, UVB or both ?
• Critical UV-induced molecular alterations to
  melanocytes ?
• Pigment- protective or promotional ?
• Role of the immune system UV effects on
  immunity?

Frances Noonan, EOH,SPHHS
3
Melanoma induced by UV irradiation of HGF/SF
transgenic mice
Noonan et al., Nature, 2001 Recio et al, Cancer
Res, 2002 in prep
Frances Noonan, EOH,SPHHS
4
Functional Mc1r is necessary for UV-induced
melanoma
YELLOW
BLACK
BLACK
Frances Noonan, EOH,SPHHS
5
Neonatal host UV irradiation promotes melanoma
outgrowth
Frances Noonan, EOH,SPHHS
Heather Poetschke-Klug et al
6
Acknowledgements

• Photobiology lab, GWUMC
• Ed De Fabo
• J. Bahn research assistants and students
• Agnieszka Wolnicka-Glubisz Stephanie Constant
  Jesse Damsker
• Glenn Merlino, NCI/NIH
• Miriam Anver, SAIC, FCRF
• Funding- NCI/NIH Elaine Snyder Cancer Research
  Fund, GWUMC

Frances Noonan, EOH,SPHHS