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  N ()  
Total 246 (100)  
Gender    
Female 125 (50.8)  
Male 121 (49.2)  
  Median age at diagnosis  
Total 57 (18-82)  
Female 58 (18-79)  
Male 55 (21-82)  
  Clinical Symptoms p0.455
Female 27 (21.6)  
Male 32 (26.4)  
Total 59 (24)  
  Incidental Diagnosis P0.168
Female 44 (35.2)  
Male 32 (26.4)  
Total 76 (30.9)  
  Referral by another specialty P0.608
Female 54 (43.2)  
Male 57 (47.1)  
Total 111 (45.1)  
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Primary site No of patients
Gastrenteropancreatic 156 (63.4)
Stomach 54 (35)
Antrum 11 (20.4)
Fundus 6 (11.1)
Corpus 37 (68.5)
Antrum 11 (20.4)
Pancreas 36 (23)
Head 20 (55.6)
Tail 10 (27.8)
Body 6 (16.7)
Duodenum 8 (5)
Jejunum 5 (3)
Ileum 10 (6)
Appendix 17 (11)
Colon 8 (5)
Rectum 18 (12)
Head and Neck 44 (17.9)
Pheochromocytoma 6 (2.4)
Lung 16 (6.5)
Typical 10 (62.5)
Atypical 6 (37.5)
Unknown Primary 24 (9.8)
Differentiation Grade  
Well 132 (58.4)
Moderate 73 (32.3)
Poor 21 (9.3)
Ki-67 LI No of patients
lt2 166
2-20 56
gt20 6
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Most common diagnostic procedures and yield of
tumor detection
  Diagnostic procedures Performed N () Positive yield N ()
Computed Tomography 202 (82.1) 117 (58.5)
Octreoscan 156 (63.4) 79 (50.6)
Chest x-ray 152 (61.8) 20 (13.2)
Gastroscopy 126 (51.2) 65 (51.6)
Abdominal ultrasound 90 (36.6) 50 (55.6)
Colonoscopy 90 (36.6) 27 (30.0)
Magnetic Resonance 85 (34.6) 63 (75.0)
Bone Scan 59 (24.0) 12 (20.7)
Endoscopic Ultrasound 27 (11.0) 20 (74.1)
Endoscopic capsule 16 (6.5) 3 (18.8)
PET 11 (4.5) 9 (81.8)
MIBG 10 (4.1) 6 (60.0)
Bronchoscopy 10 (4.1) 7 (70.0)
Enteroclysis 5 (2.0) 3 (60.0)

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Rate of positive results according to diagnostic
procedures used for staging according to primary
site
Diagnostic Procedure Head Neck n () Bronchial n () GEP n () Pheochromocytoma n () Unknown Primary n () p
Octreoscan 5 (31.3) 5 (45.5) 59 (55.1) 1 (50.0) 7 (35.0) 0.219
MIBG 1 (100.0) 0 (0) 0 (0.0) 1 (20.0) 2 (66.7) 0.429
Computed Tomography 7 (21.2) 1 (6.3) 71 (56.8) 0 (0) 4 (18.2) lt0.001
Magnetic Resonance 2 (18.2) 0 (0) 16 (30.8) 0 (0) 3 (21.4) 0.651
PET 0 (0) 0 (0) 1 (33.3) 0 (0) 1 (100.0) 0.182
x-Ray 33 (100.0) 0 (0) 82 (97.6) 2 (100.0) 14 (82.4) lt0.001
Bone Scan 18 (81.8) 9 (75.0) 7 (77.8) 3 (75.0) 9 (81.8) 0.985
Abdominal Ultrasound 5 (100.0) 2 (66.7) 32 (49.2) 0 (0) 1 (7.7) lt0.001
Gastroscopy 4 (100.0) 3 (100.0) 42 (40.0) 0 (0) 12 (85.7) lt0.001
Colonoscopy 2 (100.0) 2 (100.0) 44 (62.0) 0 (0) 15 (100.0) 0.003
Endoscopic Capsule 0 (0) 0 (0) 7 (70.0) 0 (0) 6 (100.0) 0.250
Enteroclysis 0 (0) 0 (0) 1 (25.0) 0 (0) 1 (100.0) 0.400
Endoscopic Ultrasound 1 (100.0) 0 (0) 4 (19.0) 0 (0) 2 (40.0) 0.220
Bronchoscopy 0 (0) 0 (0) 0 (0) 0 (0) 3 (100.0) 0.008
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Distribution of Ki-67 labelling index according
to type of treatment responses  
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Primary surgery and debulking procedures in NET
patients
Primary Surgical Excision Radical Non Radical
Head and Neck 40 4
Lung 8 2
GEP 110 20
Pheochromocytoma 4 2
Unknown Primary 2 1
Type of Surgery Total number of patients  
Open Surgery 128  
Endoscopic/Laparoscopic Excision 65  
Number of patients with liver metastases 49 1 pheo,3 lung, 11UP, 34GEP
Treatment of Liver Metastases Number of patients Primary (all Ki67lt20)
Liver Metastasectomy 6 1 Lung, 4GEP, 1 UP
Chemoembolization 3 GEP
Radiofrequency Ablation 4 GEP
Other 2 GEP
Number of patients with lung metastases 6 1lung, 1UP, 4GEP
Treatment of Lung Metastases 1 surgical excision 1lung
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The researchers thank IPSEN EPE!
I thank you for your attention!