Overview of SPM2 - PowerPoint PPT Presentation

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Overview of SPM2

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Overview of SPM2 From buttons to code Eamonn Walsh & Domenica Bueti SPM Statistical Parametric Mapping SPM examines every voxel location across all images and ... – PowerPoint PPT presentation

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Title: Overview of SPM2


1
Overview of SPM2
  • From buttons to code
  • Eamonn Walsh Domenica Bueti

2
SPM Statistical Parametric Mapping
  • SPM examines every voxel location across all
    images and computes a parametric map
  • Data reduction condensing information from a
    number of individuals in a statistically
    meaningful way

3
Data transformations
Statistical parametric map (SPM)
Design matrix
Image time-series
Kernel
Realignment
Smoothing
General linear model
Gaussian field theory
Statistical inference
Normalisation
p lt0.05
Template
Parameter estimates
4
Spatial Preprocessing
Model Specification and Parameter Estimation
5
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6
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7
Spatial Preprocessing
8
Spatial Preprocessing - Realign
  • Aligning hundreds of 3D brain volumes per single
    subject
  • To create a mean image

9
Spatial Preprocessing - Coregister
  • Matching the functional scan to the structural
    scan for the same individual

10
Spatial Preprocessing Slice Timing
  • Take first or middle slice as reference slice
  • Shift all other slices in time to match this
    reference slice

11
Spatial Preprocessing - Normalise
  • The same voxels in different brains are aligned
    to represent the same anatomical location.
  • Template

12
Spatial Preprocessing - Smooth
  • Blur the images prior to statistical analysis
  • FWHM Full width half maximum

13
Spatial Preprocessing - Segment
  • Images are segmented into grey and white matter
    maps

14
  • Image File fm00223_004.img
  • Realigned rfm00223_004.img
  • Realigned, Coregistered,, rrfm00223_004.img
  • Realigned, Coregistered, Normalised,
    wrrfm00223_004.img
  • Realigned, Coregistered, Normalised, Smoothed
    swrrfm00223_004.img

15
Spatial Preprocessing
16
SPM Demo
  • Spatial Preprocessing
  • Guided Tour
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