Membrane Transport III

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Membrane Transport III

• Chapter 11

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Selectivity of a K channel
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DVD Clip 45
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(No Transcript)
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DVD clip 48
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Patch Clamp Recording
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Patch Clamp Recording
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Patch Clamp Measurements of single voltage gated
Na channel
3 experiments on the same patch
cumulative of 144 experiments
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Resting Chemical Synapse
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Active Chemical Synapse
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Neuromuscular Junction in a Frog
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Three Conformations of Acetyl Choline receptor at
the neuromuscular junction
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DVD Clip 49
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Ion Channels at Neuromuscular Junction
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Motor Neuron Cell body in the Spinal Chord
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Motor Neuron Cell body in the Spinal Chord
thousands of axon terminals are stained red by
antibody that recognizes a protein in synaptic
vesicles
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Chapter 12

• Intracellular Compartments and Protein Sorting

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Major Intracellular compartments of an animal
cell
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Volumes of major intracellular compartments in a
liver cell
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Relative amount of membrane types in 2 cell types
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Complex Cortical Network of Endoplasmic Reticulum
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Cross section of liver cell
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Topological relationships between compartments of
a eukaryotic cell
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Roadmap of protein traffic inside cell
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Two ways in which a sorting signal can bebuilt
into a protein
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Some typical signal sequences
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(No Transcript)
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Nuclear Pore complexes perforate the nuclear
envelope
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Nuclear pore complexes
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Nuclear side of the nuclear envelope
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Face on view of nuclear complexes without the
membrane
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Side view of 2 nuclear pore complexes
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Transport through nuclear pore complexes occurs
through free diffusion and active transport
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Nuclear import signal direst proteins to the
nucleus
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Single amino acid mutation in signal will prevent
import into the nucleus
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Nuclear import receptors bind to nuclear porins
and nuclear localization signal of cargo protein
Different nuclear localization signals bind
different import receptors
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Ran GTP provides energy for nuclear protein import
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Ran-GTP controls cargo loading and unloading