Title: ???%20???????(Tetracycline%20Antibiotics)
1????
??????? ??56
2??? ??????????? Diuretics and Synthetic
Hypoglycemic Drugs
3??? ??????
- ????????????????????????,?????????????????
?,???????????,??????????????????????????????????
4??????
- ????????1????
- ????????2????
- ??1?????????????????90????????2????,?????
?????????
5?????????
- 1????????????
- 2????????????????
- 3????????????????
- 4?????????????
- 5??????????????-???? ?????
- 6??????????????
6 ????????????????,????????????????-???????????
??????????-?????,???????????????????????,?????????
????,???????,??????, ?????????????????1??2????????
7????? Tolbutamide
4-??-N-(???)??????
8????
- 1????????????,????,??????????
9????
- 2???????????????,?????????????????????????????????
??????,????????????,??????mp.??138????????????????
??????,??????????
10(No Transcript)
11????
- ???????????????????,?????????????
12 ???????????
- ???????,???????????
-
- ????????????,????????????????????
- ?????????????????????,???????
13????
- ????????????????,???????2????,????????????
?????????
14????????????
- 1942?,??????????????????
- 1955?,???????????????????????????????????
15 ????????????????????,????????????????????
16 ???70??,????????????????
???? gliclazide
???? glibenclamide
17 80??,????????????????
???? glimepiride
18???? Glibenclamide
N-2-4-(????)???????????-2-???-5-?????
19????
- ????????????????,?????????,????,???????????
?????????????????200?,???????,??????2??????
20??????Metformin Hydrochloride
1,1-????????
21????
- 1?????????,???????
- 2? ??????????
- 3? ?10?????????-??????-10NaOH??,3min?????
22????????
- ?????????????,???????????????????,???????????,????
????? - ?????????????,??????????
- ????????????????????????,????????
23????
- ??????????,????????????????????????,??????
?,???????????2????????????,???????????????????????
???
24????
??????? ??56
25??? ???
-
- ?????????,??????????,?????????
26 ?????
- 1??????
- 2????????
- 3??????????
27?????
- 1?????????? Mannitol
- 2? ??????? Mersalyl
- 3? ??????? Furosemide
- 4? ????????? Triamterene
- 5?a,ß-????????? Etacrynic Acid
- 6? ??????? Spironrlactone
28???????
- ????? ??? Furosemide
- ???? Etacrynic Acid
- ????????? Hydrochlorothiazide
- ????????? Acetazolamide
- ??? Spironrlactone
- ???? Triamterene
29?????????
- ???????? Furosemide
- ???? Hydrochlorothiazide
- ???? Acetazolamide
- ???????? Spironrlactone
- ???? Triamterene
30??? Furosemide
2-(2-????)??-5-(????)-4-????
31 ????
- 1????,pKa 3.9
- 2? ????? CuSO4?? ? ????
- 3? ??? ???????? ? ??
32????
- ????????????????????????????????
33???????????
????????
1937?????
??????
34???? Hydrochlorothiazide
6-?-3,4-??-2H-1,2,4-?????-7-???-1,1-????
35????
- 1????,??NaOH?????????
- 2??????
- 3?????????,??????,??????????????
36????
- ?????????????,??????,??????????????????????
??Na?Cl-?H2O?????????,???????????????????????????
?????????
37??????????
- ??????????20??50?????????????????
38(No Transcript)
39?????????
40???? Acetazolamide
N-5-(????)-1,3,4-???-2-????
41????
- 1????,????????????
- 2? ????????,?????????? ?
42????
- ?????????????,???????????????????,????812
h?????????????????,?????????,???????,????????,????
?????,???????,????????????,???????????????????????
???
43??? Spironolactone
17ß-??-3-?-7?-????-17?-??-4-?-21-??-?-??
44???? Triamterene
2, 4, 7 - ??? 6 - ????