???%20???????(Tetracycline%20Antibiotics) - PowerPoint PPT Presentation

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???%20???????(Tetracycline%20Antibiotics)

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Title: Tetracycline Antibiotics Author: yaohua Last modified by: Created Date: 5/17/2006 3:57:07 AM – PowerPoint PPT presentation

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Title: ???%20???????(Tetracycline%20Antibiotics)


1
????
  • ?????

??????? ??56
2
??? ??????????? Diuretics and Synthetic
Hypoglycemic Drugs
3
??? ??????
  • ????????????????????????,?????????????????
    ?,???????????,??????????????????????????????????

4
??????
  • ????????1????
  • ????????2????
  • ??1?????????????????90????????2????,?????
    ?????????

5
?????????
  • 1????????????
  • 2????????????????
  • 3????????????????
  • 4?????????????
  • 5??????????????-???? ?????
  • 6??????????????

6
????????????????,????????????????-???????????
??????????-?????,???????????????????????,?????????
????,???????,??????, ?????????????????1??2????????
7
????? Tolbutamide
4-??-N-(???)??????
8
????
  • 1????????????,????,??????????

9
????
  • 2???????????????,?????????????????????????????????
    ??????,????????????,??????mp.??138????????????????
    ??????,??????????

10
(No Transcript)
11
????
  • ???????????????????,?????????????

12
???????????
  • ???????,???????????
  • ????????????,????????????????????
  • ?????????????????????,???????

13
????
  • ????????????????,???????2????,????????????
    ?????????

14
????????????
  • 1942?,??????????????????
  • 1955?,???????????????????????????????????

15
????????????????????,????????????????????
16
???70??,????????????????
???? gliclazide
???? glibenclamide
17
80??,????????????????
???? glimepiride
18
???? Glibenclamide
N-2-4-(????)???????????-2-???-5-?????
19
????
  • ????????????????,?????????,????,???????????
    ?????????????????200?,???????,??????2??????

20
??????Metformin Hydrochloride
1,1-????????
21
????
  • 1?????????,???????
  • 2? ??????????
  • 3? ?10?????????-??????-10NaOH??,3min?????

22
????????
  • ?????????????,???????????????????,???????????,????
    ?????
  • ?????????????,??????????
  • ????????????????????????,????????

23
????
  • ??????????,????????????????????????,??????
    ?,???????????2????????????,???????????????????????
    ???

24
????
  • ?????

??????? ??56
25
??? ???
  • ?????????,??????????,?????????

26
?????
  • 1??????
  • 2????????
  • 3??????????

27
?????
  • 1?????????? Mannitol
  • 2? ??????? Mersalyl
  • 3? ??????? Furosemide
  • 4? ????????? Triamterene
  • 5?a,ß-????????? Etacrynic Acid
  • 6? ??????? Spironrlactone

28
???????
  • ????? ??? Furosemide
  • ???? Etacrynic Acid
  • ????????? Hydrochlorothiazide
  • ????????? Acetazolamide
  • ??? Spironrlactone
  • ???? Triamterene

29
?????????
  • ???????? Furosemide
  • ???? Hydrochlorothiazide
  • ???? Acetazolamide
  • ???????? Spironrlactone
  • ???? Triamterene

30
??? Furosemide
2-(2-????)??-5-(????)-4-????
31
????
  • 1????,pKa 3.9
  • 2? ????? CuSO4?? ? ????
  • 3? ??? ???????? ? ??

32
????
  • ????????????????????????????????

33
???????????
????????
1937?????
??????
34
???? Hydrochlorothiazide
6-?-3,4-??-2H-1,2,4-?????-7-???-1,1-????
35
????
  • 1????,??NaOH?????????
  • 2??????
  • 3?????????,??????,??????????????

36
????
  • ?????????????,??????,??????????????????????
    ??Na?Cl-?H2O?????????,???????????????????????????
    ?????????

37
??????????
  • ??????????20??50?????????????????

38
(No Transcript)
39
?????????
40
???? Acetazolamide
N-5-(????)-1,3,4-???-2-????
41
????
  • 1????,????????????
  • 2? ????????,?????????? ?

42
????
  • ?????????????,???????????????????,????812
    h?????????????????,?????????,???????,????????,????
    ?????,???????,????????????,???????????????????????
    ???

43
??? Spironolactone
17ß-??-3-?-7?-????-17?-??-4-?-21-??-?-??
44
???? Triamterene
2, 4, 7 - ??? 6 - ????
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