Acute Respiratory Distress Syndrome It

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Acute Respiratory Distress SyndromeIts so
shocking, I cant breathe!

• Heidi Ditmyer DVM
• University of Tennessee
• College of Veterinary Medicine
• Department of Pathobiology
• Tifton 2008

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Signalment

• Juvenile Female Spayed Yorkshire Terrier
• Presented to rDVM after chewing electric cord
• rDVM treated with Oxygen and diuretics

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Case 07-796

• Referred to UT
• Ventilator
• Febrile
• Died 24 hours post arrival

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Gross Findings

• Glossal and gingival ulceration
• Bilateral interstitial pneumonia
• Congenital portosystemic shunt

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Glossal ulceration
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Histology and etiology

• Fibrinous interstitial pneumonia
• Multiple possibilities
• Consistent with Acute Respiratory Distress
  Syndrome

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Acute Respiratory Distress Syndrome (ARDS)

• Acute onset
• Bilateral/diffuse pulmonary changes
• Hypoxemia
• No evidence of left atrial hypertension

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ARDS

• Secondary inflammatory response
• Macrophages ? cytokines ? enzymes ? free radicals
  ? diffuse alveolar and endothelial damage
• Differential diagnosis for any animal with
  non-cardiogenic pulmonary edema and appropriate
  risk factors

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Conclusion

• Limited lung response regardless of trigger
• Overzealous inflammatory response
• Pathophysiology not entirely understood
• Considered as differential diagnosis

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Acknowledgements

• Dr Kim Newkirk
• UT histology staff

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Thank you

• www.k9station.com

Questions?