Sickle Cell Disease

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Sickle Cell Disease
normal red blood cells
sickled red blood cells
Interview with sickle cell patient pain
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Hemoglobin
Hemoglobin subunit
Red Blood Cell
Oxygen molecule
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Chromosomal location of Hemoglobin
Chromosome 11
Hemoglobin gene
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Mutation found in Hemoglobin
Sequence of normal hemoglobin DNA CTGACTCCTGAGGAG
AAGTCT GACTGAGGACTCCTCTTCAGA Amino acids
Sequence found in sickling hemoglobin DNA CTGA
CTCCTGTGGAGAAGTCT GACTGAGGACACCTCTTCAGA Amino
acids
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Mutation found in Hemoglobin
Sequence of normal hemoglobin DNA CTGACTCCTGAGGAG
AAGTCT GACTGAGGACTCCTCTTCAGA Amino acids L T
P E E K S Sequence found in sickling
hemoglobin DNA CTGACTCCTGTGGAGAAGTCT GACTGAGGACA
CCTCTTCAGA Amino acids L T P V E K S
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Sickle Cell Hemoglobins Stick Together
Sickle Cell hemoglobin
Normal hemoglobin
No oxygen
No Oxygen

No Oxygen stuck together
No Oxygen Separate
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Effects of Sickle Cell Mutation
DNA
order of amino acids
L T P E E K S
L T P V E K S
protein shape
cell function
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Frequency of Sickle Cell Causing Mutation vs.
Frequency of Malaria Causing Microbe
of population that has HbS (Sickle Cell
mutation)
Africa
Africa
High frequency of Malaria causing microbe