PRECLINICAL STUDY OF MODIFIED CARBON SP3-NANOPARTIES

1
PRECLINICAL STUDY OF MODIFIED CARBON
SP3-NANOPARTIES

• Prof. Dr. Stavri Yanev Stavrev, Dr. Nikolay
  Odintsov

2
Abstract

• In contrast to the classic detonation
  nanodiamond, which has a three layer covering of
  oxygenic, carboxylic, carbonylic, quinone, and
  other functional groups, the new sp3
  carbon-bearing nanoparticles 1
  (SP3-nanoparticles hereafter) have only a thin
  carbon layer, which determines their positive
  biological activity.
• Pre-clinical studies confirmed that the
  SP3-nanoparticles are non-toxic. They show no
  irritant or allergic activity, no reproductive or
  immunological toxicity. Their specific
  pharmacological activity on Leukemia P388 and
  L1210 (early stage of the disease), and Lewis
  carcinoma 3LL (late stage of the disease) was
  tested. The main results are as fallows
• All animals of the control group died by the time
  of the first control point
• 80, 30 and 100 of the standard chemotherapy
  group respectively died by the second control
  point
• 100 of the third group, who received combination
  of the standard chemotherapy and SP3-
  nanoparticles, was alive by the end of the study.

3
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4
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11
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12
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13
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14
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  388.
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  1210
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15
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16
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17
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18
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• ???????? ?? ???????????? ?. ?????-??????????,
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19
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