Bioinformatics

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Bioinformatics
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• 1996???????????????
• 1998??????????????????
• 1999? ?1?????????(??????)
• 2000??????????????????
• 2003??2?????????(???????)
• 2005??3?????????(?????????)

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• ?5?????
• (?????????????????)

• SCI???? 6?(????1?) IF 10.975
• ??????20?(????4?)
• ??????72?(????9?)
• ??
• ?SCI??????????3?(BBRC 1??APS 2?)
• ???SCI?????4?(????Cell????)

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• SCI????( IF 10.975 )

1. Guo XR, Gong HX, Gao YQ, et al. A mutation in
   signal peptide of rat resistin gene inhibits
   differentiation of 3T3-L1 preadipocytes. Acta
   Pharmacol Sin, 2004, 25(12) 1705 1711.
2. Wang B, Zhang M, Guo XR, et al. Identification
   and characterization of NYGGF4, a novel gene
   containing a phosphotyrosine-binding (PTB) domain
   that stimulates 3T3-L1 preadipocytes
   proliferation. Gene, 2006, 379(1) 132-140.
3. Min Zhang, Bin Wang, Xi-rong Guo, et al.
   Overexpression of uncoupling protein 4 promotes
   proliferation and inhibits apoptosis and
   differentiation of preadipocytes. Life Sci, 2006,
   79(15) 1428-1435.
4. Haixia Gong, Yuhui Ni, Xirong Guo, et al.
   Resistin promotes 3T3-L1 preadipocyte
   differentiation. Eur J Endocrinol, 2004, 150(6)
   885-892.
5. Gong Hai-Xia, Guo Xi-rong, Fei Li, et al.
   Lipolysis and apoptosis of adipocytes induced by
   neuropeptide Y-Y5 receptor antisense
   oligodeoxynucleotides in obese rats. Acta
   Pharmacol Sin, 2003, 24(6) 569-575.
6. LIU Feng, GUO Xi-rong, GONG Hai-xia, et al. A
   resistin binding peptide selected by phage
   display inhibits 3T3-L1 preadipocyte
   differentiation. Chin Med J, 2006, 119(6)
   496-503.

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• SCI?????6?
• ????????????

1. Duff E, et al. Ciliary neurotrophic factor
   injected icv induces adipose tissue apoptosis.
   Apoptosis, 2004, 9(5) 629-634.
2. Jeyakumar SM, et al. Vitamin A supplementation
   induces adipose tissue loss through apoptosis in
   lean but not in obese rats of the WNIN/Ob strain.
   J Mol Endocrinol, 2005, 35(2) 391-398.
3. Zhang YL, et al. Establishment of liver specific
   glucokinase gene knockout mice a new animal
   model for screening anti-diabetic drugs. Acta
   Pharmacol Sin, 2004, 25(12) 1659-1665.
4. LIU Feng, et al. A resistin binding peptide
   selected by phage display inhibits 3T3-L1
   preadipocyte differentiation. Chin Med J, 2006,
   119(6) 496-503.
5. Guo X, et al. A mutation in signal peptide of rat
   resistin gene inhibits differentiation of 3T3-L1
   preadipocytes. Acta Pharmacol Sin, 2004, 25(12)
   1705 1711.
6. LIU Feng, et al. A resistin binding peptide
   selected by phage display inhibits 3T3-L1
   preadipocyte differentiation. Chin Med J, 2006,
   119(6) 496-503.

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Eur J Endocrinol????????????????? Resistin????????
????NCBI nucleotide Database
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• ????SCI??3?( IF 5.246 )

1. Jie Qiu, Yuhui Ni, Xirong Guo, et al.
   Identification of differentially expressed genes
   in omental adipose tissues of obese patients by
   Suppression Subtractive Hybridization.
   Biochemical and Biophysical Research
   Communications, ??
2. Hong-qi FAN, Nan GU, Xi-rong Guo, et al.
   Prolonged exposure to resistin inhibits glucose
   uptake in rat skeletal muscles. Acta Pharmacol
   Sin, ???
3. Nan GU, Shu-ping Han, Xi-rong Guo, et al.
   Resistin-binding peptide antagonizes role of
   resistin on white adipose tissue. Acta Pharmacol
   Sin, ??

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• ????SCI??4?

1. Yuhui Ni, Wang B, Xirong Guo, et al. Human
   C10orf116, an adipose-specific novel gene,
   greatly promote 3T3-L1 preadipocyte adipogenisis.
   2006?????????????????,???Cell
2. Liu Feng Qiu Jie, Guo Xi-rong, et al. A Paradox
   Insulin inhibits resistin expression and
   secretion while resistin induces insulin
   resistance. ???Molecular and Cellular
   Endocrinology
3. WANG Bin, ZHANG Min, LIU Feng, et al. Resistin
   Binding Peptide Stimulates Insulin Secretion in
   RINm5F Insulinoma Cells. ???Chinese Medical
   Journal
4. GU Nan, LIU Shi, GUO Xi-rong, et al. Verapamil
   Inhibits 3T3-L1 Preadipocytes Differentiation.
   ???Chinese Medical Journal

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• ????

• ?????????32?, ?NCBI GenBank????5?
• AY272059 (AAP32478.1)
  NM_212517(NP_997682.1)
• AY512661
• AY313923(AAP83790.1)
• AY292988(AAP44117.1)
  NM_181768(NP_861433.1)
• AY317148 (AAP79437.1)
  
• ??????C10orf116?NYGGF4???????????????????????
• ??????(?UCP4?TSG6?)?????????????????

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• ????

1. ????Resistin????????????????,????Resistin???????Le
   u9Val ,??????????????
2. ?????Resistin?L6??????? H4IIE???????????????????,?
   ?????????????
3. ????????Resistin????,???????????beta???????
4. ?????????????NPY Y5????????????????

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• ??????????

1. ???, ?. Resistin???????????????????(200610041152.1
   )
2. ???, ?. NYGGF4?????????????????????(200610041169.7
   )
3. ???, ?. NYGGF5????????????????????????(20061008610
   7.8)

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• ??????????????

• ?????Y Y5??????????????????????????
• 2004? ?????????
  ????
• ?????Y Y5?????????????????????
• 2004? ??????????
  ????
• ?????Y Y5?????????????????????
• 2003?
  ??????????
  ????

?????????? ??????(???)??
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• ?5????????
• (???174?)

• NYGGF4???????????GLUT4???????(30571978)
• ????????,25.0??,2006.1-2008.12
• Resistin???????????????(30371502)
• ????????,20.0??,2004.1-2006.12
• Resistin???????????????????(BK2001120)
• ?????????,6??,2002.1-2004.12
• UCP4???TSG-6????????????????????
• ????????????,5??,2003.1-2006.12
• ??Resistin????????????????????
• ?????????????,8??,2002.1-2004.12
• ????????????????????(RC2002061)
• ??????135????????,100?,2002.1-2005.12
• Resistin???????????????(CX2001005)
• ??????????,10.0??,2002.1-2004.12

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• Acta Pharmacol Sin reviewer

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thanks