Title: Alzheimer
1Alzheimers Disease
BRAIN, THE FINAL FRONTIER
2Alzheimers Disease
3Amyloid-b precursor protein
?-secretase
b-secretase
g-secretase
?-amyloid deposition
4Mechanism of Neurodegeneration in Alzheimers
Disease
APP
Glial Activation
Presenilin
Presenilin
Ab 1-40, 1-42
Neurodegeneration
Amyloid Deposition
5Glial Activation in Aging and Disease
Neuronal Dysfunction or Neurodegeneration
Glial Activation (Inflammation)
Shift
Shift
Age
6APOPTOSIS
APOPTOSIS
Phagocytosis and Degradation
7Fragmented DNA (Apoptosis) in the hippocampus
Aged Control
8Amyloid Plaque and Apoptosis
9Neuro-fibrillary Tangles and Apoptosis
10Astrocyte and Apoptosis
11GFAP mRNA Expression in the Aged Memory Impaired
Model Rat
Regression Analysis of GFAP mRNA Expression in
the Hippocampus against the Memory Score
12APP mRNA Expression in the Aged Memory Impaired
Model Rat
Ci/g tissue
Regression Analysis of APP mRNA Expression in the
Hippocampus against the Memory Score
Young
Aged unimpaired
Aged impaired
13Mn-SOD mRNA Expression in the Aged Memory
Impaired Model Rat
Ci/g tissue
Regression Analysis of Mn-SOD mRNA Expression in
the Hippocampus against the Memory Score
49.28 52.13 54.97 57.82 60.66 63.51 66.36 69.20 72
.05 74.89 77.74 80.59 83.43 86.28 89.12 91.97 94.8
2 97.66 100.51 103.35 106.20 109.04 111.89 114.74
117.58 120.43 123.27 126.12 128.97 131.81 134.66 1
37.50
Young
Aged unimpaired
Aged impaired
14APP ISHH with GFAP Immunostaining in the Aged
Memory Impaired Model Rats
Aged Impaired
matured
15GFAP ISHH (astrocytes marker) with 4G8 (Ab)
Immuno-histochemistry in PS1-APP TM
16APP ISHH with GFAP Immuno-histochemistry
(astrocytes marker) in PS1-APP TM