Previously on Bio308

1
Previously on Bio308
Introduction to Bipolar
Disorder
Parts of a neuron
Types of synapses
Parts of a synapse
2
Now on Bio308
Compounds that mediate signaling
Types of responses that occur
Post-synaptic cell receptors
3
Compounds that mediate signaling
Neurotransmitter vs Neuropeptide vs Neurohormone?
Whats a catechol?
Recognize any structures?
4
Compounds that mediate signaling
Catecholamines and Bipolar disorder
Catecholamine theory of affective disorder
Mania and depression caused by change in The
amount of activity at noradrenergic synapses
5
Problems
Use of amino acids as neurotransmitters
Use of nucleotides/nucleosides as
neurotransmitters
Use of peptides for paracrine or endocrine
signaling
Why might these things pose problems?
How does the body get around those problems?
6
Ions and the cell
Voltage and membrane potential
Does the type of ion(s) matter?
Concentration gradients and Ex
Where are these ions?
Ca
Na
K
Cl-
7
Excitatory vs Inhibitory synapses
What are they?
How do ions play a role in these responses?
What lets the ions in?
8
Types of neurotransmitter receptors
9
Types of neurotransmitter receptors
Similarities?
Differences?
10
Receptors
2 types of acetylcholine receptors
same ligand different response
Glutamate
Non-NMDA
Mg
2 types of glutamate receptors
NMDA
Removal of Mg
Adapted from fig 21-40
11
Next on Bio308
Neurotransmitters Neurotransmitter
receptors
Soluble
Transmembrane
How do they get where they need to be?
Part I soluble neuropeptide From DNA to protein
DNA?transcription?mRNA?translation?protein All in
one day!