Tam

1

• Tamás Kiss, PhD (Wigner, Pfizer)
• Conductance based modeling of hippocampal
  cellular and network activity
• McCulloch-Pittslevel modeling of hippocampal
  function
• Analysis of electrophysiological data sets
• Pharmaco-behavioral experimentation with rodents
• Interested in the normal and pathological
  information processing in the hippocampo-cortico-t
  halamic network during wakefulness and sleep.

2

• Accumulation of Aß might cause
• Hyperexcitability due to neural depolariztion
  caused by membrane permeabilzation
• Pathological single-cell rhythms resulting from
  changing the activity of various (L-type Ca2,
  A-type K, IK, ICT, etc.) ion channels
• Network instability following complex modulation
  of synaptic transmission
• Decreased network activity due to cell death

Hypothesis changing levels of amyloid-ß modulate
hippocampal network activity in a nonlinear
fashion via affecting synaptic and non-synaptic
cellular elements. This can be modeled in a
computer and used to understand drug mechanism of
action and predict efficacy.
Aßrelated non-linear decrease of hippocampal ?
power in transgenic mice. From Scott et al.,
Neurobiol of Aging, 2012.