Virology 1

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Virology 1

• PM2 Pathophysiology

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Virus

• infectious particle
• DNA or RNA as its genetic material.
• Needs to infect a host cell for replication
• toxic, poison
• virology

Tobacco mosaic virus
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Baltimore classification of viruses

• based on the mechanism of mRNA production.
• I dsDNA viruses
• Adenoviruses, Herpesviruses, Poxviruses
• II ssDNA viruses ()sense DNA
• Parvoviruses
• III dsRNA viruses
• Reoviruses
• IV ()ssRNA viruses ()sense RNA
• Picornaviruses, Togaviruses
• V (-)ssRNA viruses (-)sense RNA
• Orthomyxoviruses, Rhabdoviruses
• VI ssRNA-RT viruses ()sense RNA Retroviruses
• VII dsDNA-RT viruses Hepadnaviruses

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Icosahedral
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Helical viruses

• not grouped in capsomeres
• ribbon-like structure        

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Complex
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Start
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Forms of damage to the host cells

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• 1. Cell lysis
• 2. Production of toxic substances
• 3. Cell transformation
• 4. Induction of formation of substances
• 5. Induction of structural alterations in the
  host cell Nuclear (including chromosomal) or
  Cytoplasmic changes

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PRIONS

• Contain protein only
• small, proteinaceous particles
• Kuru
• Creutzfeldt-Jakob disease syndrome

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DNA VIRUSES

• Herpes Virus
• Hepatitis B virus
• Adenovirus
• Parvovirus
• Polyomavirus
• Papillomavirus

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Herpesvirus

• herpes simplex virus type 1
• herpes simplex virus type 2
• varicella-zoster virus
• Cytomegalovirus
• Epstein-Barr virus
• human herpesvirus 6
• human herpesvirus 7
• Kaposi's Sarcoma herpesvirus.

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HSV

• Causes encephalitis
• DOC Acyclovir

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Varicella (chickenpox)
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Herpes Zoster
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CMV 3 types of infections

• 1. Congenital cytomegalovirus infection
• retinitis
• petechial/purpuric skin rash
• central nervous system defects
• 2. Mononucleosis syndrome
• fever, malaise, atypical lymphocytosis,
  pharyngitis
• 3. immunocompromised individuals
• life-threatening disease from either primary
  or reactivated infection

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EBV

• Epstein-Barr virus mononucleosis most common
  that occurs in humans.
• Infectious mononucleosis
• Most cases subclinical, () serology
• Main cause of malignant B-cell lymphoma in organ
  transplants
• PTLDpost-transplant lymphoproloferative disorder

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