Presentazione di PowerPoint

1
(No Transcript)
2
(No Transcript)
3
(No Transcript)
4
(No Transcript)
5
(No Transcript)
6
(No Transcript)
7
GSEC STUDY CURRENT DATA ENTRY STATUS (Last
Update October, 2005) Investigators 111
Studies 203 Total subjects
73,154 Cases 31,977 Controls 41,177

8

• DISTRIBUTION OF CANCER CASES IN THE DATA SET BY
  SITE
• SITE N ()
• --------------------------------------------------
  ---------
• Lung 10,992 (34)
• Breast 4878 (15)
• Bladder 3753 (12)
• Head and neck 2912 (9)
• Colon 1930 (6)
• Skin 1632 (6)
• Leukemia 1646 (5)
• Prostate 873 (3)
• Ovary 148 (1)
• Uterus 490 (1)
• Others 2723 (8)

9
Distribution of genetic polymorphisms available
in the data-set
10
EXAMPLE OF DATA AVAILABLE THROUGH GSEC
NAT2 NAT CYP 1A1 GST M1 GST M3 CYP 2E1 GST T1 GST P1 HPX CYP 2D6 ADH NQO CYP 1B1 MTH FR
BLADDER                            
Cases 2031 562 654 2971 0 1012 2023 374 213 1211 115 371 0 0
Controls 1040 642 1308 3514 0 1379 3012 821 293 1038 131 381 0 0
BREAST                            
Cases 850 396 992 3142 275 372 2050 1242 598 126 0 323 1715 433
Controls 1128 598 1742 3668 266 431 1745 868 586 212 0 283 1602 266
LUNG                            
Cases 1590 539 4158 8040 976 1752 6779 2815 1670 1439 0 878 113 0
Controls 3379 671 6219 11650 1084 2813 9965 3496 2604 2218 166 935 56 635
11
HuGE GSEC reviews
12
(No Transcript)
13
(No Transcript)
14
(No Transcript)
15
(No Transcript)
16
Communication of results

• Publications
• Yearly e-mail to co-investigators
• Web site

17
METABOLIC GENE POLYMORPHISM FREQUENCIES IN
CONTROL POPULATIONS

• Seymour Garte, Laura Gaspari, Anna-Karin
  Alexandrie, Christine Ambrosone, Herman Autrup,
  Judith L. Autrup, Helena Baranova, Lise Bathum,
  Simone Benhamou, Paolo Boffetta, Christine
  Bouchardy, Katja Breskvar, Jurgen Brockmoller,
  Ingolf Cascorbi, Margie L. Clapper, Christiane
  Coutelle, Ann Daly, Marco Dell'Omo, Vita Dolzan,
  Carolyn M. Dresler, Anthony Fryer, Aage Haugen,
  David W. Hein, Allan Hildesheim, Ari Hirvonen,
  Ling-Ling Hsieh, Magnus Ingelman-Sundberg, Ivan
  Kalina, Daehee Kang, Masahiro Kihara, Chikako
  Kiyohara, Pierre Kremers, Philip Lazarus, Loic Le
  Marchand, Maria Celeste Lechner, Ester M.M. van
  Lieshout, Stephanie London, Johannes J. Manni,
  Christine M. Maugard, Shunji Morita, Valle Nazar-
  Stewart, Kazumasa Noda, Yoshio Oda, Fritz F.
  Parl, Roberta Pastorelli, Irene Persson, Wilbert
  H. M. Peters, Agneta Rannug, Timothy Rebbeck,
  Angela Risch, Liliane Roelandt, Marjorie Romkes,
  David Ryberg, Jan Salagovic, Bernadette Schoket,
  Janeric Seidegard, Peter G. Shields, Edith Sim,
  Daniel Sinnet, Richard C. Strange, Isabel
  Stucker, Haruhiko Sugimura, Jordi To-Figueras,
  Paolo Vineis, Mimi C. Yu, and Emanuela Taioli.

18
StrenghtsWeaknesses
19
SOME RESULTS FROM GSEC ON EFFECTS OF METABOLIC
GENE VARIANTS

• Association (O.R.)
• GSTM1, Smoking and Colorectal Cancer NS
• GSTM1, Head and Neck Cancer 1.3
• GSTT1, Head and Neck Cancer 1.2
• GSTM1, Smoking and Lung Cancer 1.1
• NAT2 and Bladder Cancer 1.4
• (interaction with smoking)

20
THE WEB SITE (www.gsec.net)

• Was started at the time the study started
• Includes updates on data colelction,
  investigators who joined the group, publications
  deriving from the project, a medline on genetic
  susceptibility and cancer
• It is linked with the HuGE website