Chen C-J, et al. JAMA. 2006;295:65-73; Ganem D

1
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2
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Chen C-J, et al. JAMA. 200629565-73 Ganem D
Prince AM. N Eng J Med. 20043501118-29
Fattovich G. Semin Liver Dis. 20032347-58.
3
??????? EASL ?? 2009?
?????????????????????????????????????HCC
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EASL Clinical Practice Guidelines Panel. J
Hepatol. 200950227-42.
4
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1. Keeffe E. Clin Gastroenterol Hepatol.
20086131541. 2. Liaw YF, et al. Hepatol Int.
2008226383. 3. Lok A McMahon B. Hepatology.
20074550739.
5
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1. Keeffe E. Clin Gastroenterol Hepatol.
20086131541. 2. Liaw YF, et al. Hepatol Int.
2008226383. 3. Lok A McMahon B. Hepatology.
20074550739.
6
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EASL Clinical Practice Guidelines. J Hepatol
2009 50227-242.
7
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HBeAg() ETV ???? (ETV-022?ETV-901)
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ETV-901????????????? 5????,5???PCR???? (NCM).
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Oct 31Nov 4 ,2008, San Francisco, USA. Poster
893. Hepatology. 200848(4, suppl)705A.
8
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????HBV??
??????,???????,????????1-3
1. Keeffe E. Clin Gastroenterol Hepatol.
20086131541. 2. Liaw YF, et al. Hepatol Int.
2008226383. 3. Lok A McMahon B. Hepatology.
20074550739.
9
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1. Lok ASF, et al. Hepatology. 200745507-39.
2. Fung S Lok A. Antivir Ther. 20049101326.
3. Leung NWY, Hepatology. 2001331527-1532 4.
Zoulim F, et al. Antiviral Res. 2004641-15. 5.
Sheldon J Soriano V. J Antimicrob Chemotherapy
20084766-8. 6. Pawlotsky JM, et al.
Gastroenterology 2008134405-15.
10
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1.Locarnini S, et al. J Hepatol. 200644422-31.
2. Zeffix (lamivudine) SmPC. February 2008. 3.
Sebivo (telbivudine) SmPC. June 2007. 4.
Hepsera (adefovir) SmPC.October 2007. 5.
Baraclude (entecavir) SmPC. February 2009. 6.
Lok AS, et al. Hepatology 200746254-65. 7.
Villet S, et al. J Hepatol 200746531-8.
11
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??????? ??HBeAg ()?? ??
HBeAg(-)??
1. Locarnini S. Hepatol Int. 20082147-51. 2.
Lai CL, et al. N Engl J Med, 20073572576-8
3. Liaw YF, et al. Gastroenterology
2009136486-95. 4. Tenney et al. EASL April
2226, 2009, Copenhagen, Denmark, Oral
Presentation 1761.
12
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1. Keeffe E. Clin Gastroenterol Hepatol.
20086131541. 2. Liaw YF, et al. Hepatol Int.
2008226383. 3. Lok A McMahon B. Hepatology.
20074550739.
13
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1
5 ?
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3 ?
????(??37?)
1. Dienstag JL, et al. Gastroenterology
2003124105-17 2. Hadziyannis SJ, et al.
Gastroenterology 20061311743-51. 3. Liaw Y-F,
et al. 59th AASLD meeting, Oct 3Nov4, 2008, San
Francisco, USA. Poster 894. Hepatology
200848706A. 4. Takehara T, et al. 18th APASL
meeting, March 2326, 2008, Seoul, Korea. Poster
PP007.
14
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4, 2008, San Francisco, USA. Poster 894.
Hepatology 200848706A.
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Chang TT, et al. Hepatol Int 20093116(Abstract
PE119), and poster presentation at APASL 2009.
16
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1. Keeffe E. Clin Gastroenterol Hepatol.
20086131541. 2. Liaw YF, et al. Hepatol Int.
2008226383. 3. Lok A McMahon B. Hepatology.
20074550739.
17
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EASL Clinical Practice Guidelines Management of
chronic hepatitis B. J Hepatol. 200950227-42.
18
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