Introduction to Metabolism

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Introduction to Metabolism

• Jack Blazyk

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Design of Metabolism
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Design of Metabolism
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Design of Metabolism
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Design of Metabolism
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Design of Metabolism
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Allosteric Regulation
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Allosteric Regulation
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Allosteric Regulation
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Covalent Modification
(e.g., reversible phosphorylation)
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Covalent Modification
(e.g., reversible phosphorylation)
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Genetic Regulation
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High-Energy Phosphates
Enol
Example Phosphoenolpyruvate (PEP)
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High-Energy Phosphates
Acyl
Example 1,3-Bisphosphoglycerate
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High-Energy Phosphates
Amino
Example Creatine phosphate
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High-Energy Phosphates
Pyro (Phosphoanhydride)
Example Adenosine triphosphate (ATP)
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Hydrolysis of Phosphates
Enol -15 Acyl -10 Amino -10 Pyro -7
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Adenosine Pool
ATP
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Adenosine Pool
ADP
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Adenosine Pool
AMP
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ATP Hydrolysis
ATP
ADP
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Major Fuel Molecules
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Located in mitochondrial matrix
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Ins and Outs
In
Out
2 CO2 CoA - SH 3 NADH 3 H 1 FADH2 GTP H2O
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(No Transcript)
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Well-FedConditions
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Only in America
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Well-Fed Liver
Glycogenesis
Glycolysis
Cholesterol Synthesis
Pentose Shunt
Triglyceride Synthesis
Fatty Acid Synthesis
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Well-Fed Adipose
Pentose Shunt
Glycolysis
Cholesterol Synthesis
Triglyceride Synthesis
Fatty Acid Synthesis
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Well-Fed Muscle
Glycogenesis
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Well-Fed State
Brain
Pancreas
Gut
Portal Vein
Liver
Adipose
Lymphatics
Muscle
RBC
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FastingConditions
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Fasting Liver
Glycogenolysis
Gluconeogenesis
Ketone Body Synthesis
Fatty Acid Oxidation
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Fasting Adipose
No Uptake
Triglyceride Breakdown
Fatty Acid Oxidation
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Fasting Muscle
No Uptake
Ketone Body Utilization
Fatty Acid Oxidation
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Early Fasting State
Brain
Pancreas
Gut
Portal Vein
Adipose
Liver
Lymphatics
Muscle
RBC
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Extended Fasting State
Brain
Pancreas
Gut
Portal Vein
Adipose
Liver
Lymphatics
RBC
Muscle
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