Monday, 19 September Chapter 11 The Endocrine System

1
Monday, 19 SeptemberChapter 11 The Endocrine
System
Two 1QQs returned on Piano
Lab this week Analyzing a research paper
First Endocrine Case study.Lab next week Four
more cases in endocrinology Pick up your
photocopy from the Piano, read it before lab!
King DS, Sharp RL, Vukovich MD, Brown GA,
Reifenrath TA, Uhl NL, Parsons KA . Effect of
oral androstenedione on serum testosterone and
adaptations to resistance training in young men
a randomized controlled trial. JAMA 1999
281(21)2020-8
Wednesday, 21 SeptemberChapter 6 The Nervous
SystemRead sections A and B
2
1QQ 6 for 830
Write the number of the one question you choose
to answer.

• TSH stimulates
• The thyroid gland to take up iodide
• the synthesis and secretion of thyroglobulin
• The uptake of thyroglobulin from the colloid
• Follicular cells of the thyroid gland to grow
• The hypothalamus to secrete more TRH.
  OR
• In response to a drop in blood pressure
• Juxtaglomerular cells of the kidney secrete less
  renin
• Elevated levels of aldosterone stimulate thirst
• Newly-formed angiotensin I causes
  vasoconstriction
• Elevated levels of aldosterone promote Na
  retention by the kidneys
• The liver produces more Angiotensin II.

3
1QQ 6 for 930
Write the number of the one question you choose
to answer.

• TSH stimulates
• The thyroid gland to take up iodide
• the synthesis and secretion of thyroglobulin
• The uptake of thyroglobulin from the colloid
• Its target cells to incorporate more Na/K
  ATPase into their membranes
• The hypothalamus to secrete more TRH.
  OR
• In response to a drop in blood pressure
• Juxtaglomerular cells of the kidney secrete less
  renin
• Elevated levels of Angiotensinogen stimulates
  thirst
• Newly-formed angiotensin I causes
  vasoconstriction
• Elevated levels of aldosterone promote Na
  retention by the kidneys
• The liver produces more Angiotensin II.

4
Fig. 11.12a
S3
Receives input from many regions of brain many
factors Affect its function Homeostatsis center.
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Fig. 11.12b
S4
NeurohypophysisAdenohypophysis
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Vasopressin ( Antidiuretic hormone)Oxytocin
6
Tropic hormones control the function Trophic
hormones promote survival and growth of targets
S 6
Hypothalamo-hypophyseal portal system
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Tropic hormones control the function Trophic
hormones promote survival and growth of targets
S 7
Short-loop Neg. Feed.
Long-loop negative feedback
8
Who Cares?
9
EndemicGoiter
S 4

• Symptoms of hypothyroidism
• Levels of TSH and TH?
• Explain enlarged thyroid gland
• Cause Inadequate dietary intake of iodine
• Treatment?

Goiter
Elevates basal metabolic rate,potentiates
response to EPI
If hypothyroid during pregnancycretinism
congenital hypothyroidism
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Classification of Endocrine disorders
S 3

• Hypersecretion
• Primary
• Secondary
• Hyposecretion
• Primary
• Secondary

hypothalamus
CRH ACTH Cortisol
Anterior pituitary
Adrenal Cortex
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Who else Cares?
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Aunt Dot
S 5
13
Graves Disease
S 6
Blood testTSH levels low TH levels high
TRH from Hypothal.
TSH from Ant. Pit.
T3 and T4 from Thyroid gland
?Lipolysis and fuel mobilization
Weight loss
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Graves Disease
S 7
Treatment Radioactive Iodine Mechanism..
15
S 8
Physical traumaProlonged exposure to
coldProlonged intense exerciseInfectionSleep
deprivationPainFrightEmotional distress
Vasopressin
Basal levels of Cortisol Required for normal
sensitivity to EPI symptoms of excess cortisol
are..
Clinical example treatment of chronic
inflammation (e.g. arthritis) can lead to
Cushings Syndrome!
?Cortisol secretion from Adrenal Cortex
Cushings Syndrome
Excess Cortisol from 1) adrenal cortex tumor
(primary) or 2) hypersecretion of ACTH from
anterior pituitary (secondary)