Understanding Soy

1
Understanding Soy

• Soy has been consumed by Asian cultures for
  thousands of years.
• Soy is a legume that is so nutritionally complete
  that it sustained Eastern populations through
  drought and famine.
• Composed of
• Protein - Carbohydrate
• Fat - Fiber
• Phytonutrients - Isoflavones
• Other isoflavone rich foods include garbanzo
  beans and sprouts (Red Clover)

2
The forms of soy

• Soy has been used and studied in various forms
• Whole soybeans-raw and cooked
• Protein isolates-with balanced and unbalanced
  isoflavone content
• Balanced isoflavone isolates
• Single isoflavone isolates
• The more imbalanced the isoflavones the greater
  the chance for negative affects.

3
Why is their confusion around soy?

• Negative articles regarding soy typically focus
  on only one particular study.
• Thorough evaluation of existing research will
  reveal the positive health benefits of soy.
• Also, certain companies and/or individuals are
  exploiting negative research as a marketing
  tactic.

4
Frequently Asked Questions about Soy

• Is GMO soy is used in Metagenics products?
• Do Metagenics soy products have the proper
  balance of isoflavones?
• Is soy beneficial for tissue health? Menopause?
  Bone health?
• Do you think people are eating too much soy?
• Do soy products compromise male reproduction?
• Isnt it better to use a more complete protein?
• Do I have to use fermented soy products to
  achieve therapeutic benefits?
• Does soy inhibit thyroid function?
• How common is soy allergy?

5
Is GMO soy is used in Metagenics products?

• NO. We use only DNA identified soy to guarantee
  the purity of our ingredients.
• We test every batch to ensure we are using only
  the purest soy protein.
• Our Identity Preserved soy allows us to trace
  the source of the raw material and ensure it is
  not genetically modified.
• Being certified by regulatory agencies of NNFA,
  NSF and TGA shows how seriously we take the
  quality of all of our products.
• Over 2 million spent in 2005 on QC/QA

6
Do Metagenics soy products have a natural balance
of isoflavones?

• Yes. Our soy products are evaluated to verify
  they have natural ratios of the isoflavones
  Genistein and Daidzein.
• Isoflavones from soy are 100 to 1000 times weaker
  than estradiol.
• Collins. Steroids 199762365
• Our soy products carry a 11 ratio of these
  isoflavones which is identical to what is found
  in tofu.
• Our 35 full-time scientists led by Dr. Jeffrey
  Bland are involved in every aspect of product
  formulation, research and testing.
• Over 5 million spent in 2005.

7
Is soy beneficial for tissue health?

• Yes. Soy contains various beneficial agents for
  tissue health
• Kennedy AR. The evidence for soybean products as
  cancer preventive agents. J Nutr 1995125(3
  Suppl)733S-43S.
• Cultures that eat soy have shown an improvement
  in colon and specific hormone-related tissue
  health issues.
• Shu XO, Jin F, Dai Q, et al. Soyfood intake
  during adolescence and subsequent risk of breast
  cancer among Chinese women. Cancer Epidemiol
  Biomarkers Prev 200110(5)483-88.
• Lamartiniere CA, Moore JB, Brown NM, Thompson R,
  Hardin MJ, Barnes S. Genistein suppresses mammary
  cancer in rats. Carcinogenesis 199516(11)2833-40
  .
• Human trials involving post-menopausal women
  demonstrate a significant shift in healthy
  estrogen metabolism.
• Xu X, Duncan AM, Merz BE, Kurzer MS. Effects of
  soy isoflavones on estrogen and phytoestrogen
  metabolism in premenopausal women. Cancer
  Epidemiol Biomarkers Prev 19987(12)1101-08.
• Xu X, Duncan AM, Wangen KE, Kurzer MS. Soy
  consumption alters endogenous estrogen metabolism
  in postmenopausal women. Cancer Epidemiol
  Biomarkers Prev 20009(8)781-86.

8
Is soy beneficial for breast health?

• Research is far from conclusive on this issue and
  researchers are urging caution for women
• However, a distinction should be made between the
  clear benefit of soy protein for cardiovascular
  health and the inconclusive role of isoflavones
  for breast tissue health.
• Henkel J. U.S. Food and Drug Administration. Soy
  Health claims for soy protein, questions about
  other components. Available at
  http//www.fda.gov/fdac/features/2000/300_soy.html
  . Accessed August 4, 2004.
• Messina M, Erdman J Jr, Setchell KD. Introduction
  to and perspectives from the Fifth International
  Symposium on the Role of Soy in Preventing and
  Treating Chronic Disease. J Nutr
  2004134(5)1205S-06S.
• Xu X, Duncan AM, Merz BE, Kurzer MS. Effects of
  soy isoflavones on estrogen and phytoestrogen
  metabolism in premenopausal women. Cancer
  Epidemiol Biomarkers Prev 19987(12)1101-08.
• Xu X, Duncan AM, Wangen KE, Kurzer MS. Soy
  consumption alters endogenous estrogen metabolism
  in postmenopausal women. Cancer Epidemiol
  Biomarkers Prev 20009(8)781-86.

9
Does soy benefit menopausal women?

• Yes. The research shows a great correlation with
  reducing hot flashes and other menopausal issues
  by consuming soy products.
• Consumption of soy protein containing isoflavones
  decreased the intensity of hot flashes.
• Washburn S, Burke GL, Morgan T, Anthony M. Effect
  of soy protein supplementation on serum
  lipoproteins, blood pressure, and menopausal
  symptoms in perimenopausal women. Menopause
  19996(1)7-13.
• The majority of studies in menopausal women have
  shown improvement of hot flashes following soy
  consumption.
• The role of isoflavones in menopausal health
  consensus opinion of The North American Menopause
  Society. Menopause 20007(4)215-29.
• Eden J. Phytoestrogens and the menopause.
  Baillieres Clin Endocrinol Metab
  199812(4)581-87.
• Dalais FS, Rice GE, Wahlqvist ML, et al. Effects
  of dietary phytoestrogens in postmenopausal
  women. Climacteric 19981(2)124-29.

10
Is soy beneficial for bone health?

• Yes. Studies have shown that the isoflavones
  that are found in soy stimulate bone formation
  and reduce bone breakdown.
• Soy isoflavones have been found to have a
  positive effect on bone health.
• Migliaccio S, Anderson JJ. Isoflavones and
  skeletal health are these molecules ready for
  clinical application? Osteoporos Int
  200314(5)361-68.
• Isoflavones stimulate osteoblastic bone formation
  and inhibit osteoclastic bone breakdown.
• Brynin R. Soy and its isoflavones a review of
  their effects on bone density. Altern Med Rev
  20027(4)317-27.

11
Do you think people are eating too much soy?

• Americans eat very little soy products when
  compared to Asian populations.
• While Asian populations consume an average of 10
  to 50 grams of soy per day, Americans generally
  consume only 1 to 3 grams daily.
• Limer JL, Speirs V. Phyto-oestrogens and breast
  cancer chemoprevention. Breast Cancer Res
  20046(3)119-27.
• In fact, one-quarter of Americans reported
  consuming soy foods once a week or more, while
  38 admitted to never consuming soy products.
• United Soybean Board. National Report, 2004-2005.
  Consumer attitudes about nutrition Insights
  into nutrition, health, and soyfoods. Available
  at http//www.talksoy.com/pdfs/ConsumerAttitudes2
  004.pdf. Accessed August 5, 2004.

12
Do soy products compromise male reproduction?

• NO. Studies done with balanced soy isoflavones
  do not show negative impact on male
  reproduction.
• These studies done with one isoflavone or by
  injecting isoflavones directly into the blood
  create much of the negative concern on soy.
• Genistein was shown in cell cultures to
  negatively impact human sperm's ability to
  fertilize the female egg.
• Professor Lynn Fraser of King's College London,
  European Society for Human Reproduction and
  Embryology
• Only when plant estrogens are injected, leading
  to high blood levels are adverse effects seen in
  research animals.
• US Center for the Evaluation of Risks to Human
  Reproduction (CERHR) or the National Institute of
  Environmental Health Services and National
  Toxicology Program March 20, 2006.

13
Do soy products compromise male reproduction?

• Four published clinical trials investigating the
  effects of soy isoflavone consumption in men and
  reported that there are no adverse effects of soy
  isoflavone consumption on sperm quality.
• Persky VW, Turyk ME, Wang L, et al. Effect of soy
  protein on endogenous hormones in postmenopausal
  women. Am J Clin Nutr 200275(1)145-53.
• Consumption of isoflavone supplements at the
  level of 40 mg daily had no effect on semen
  quality.
• Mitchell JH, Cawood E, Kinniburgh D, Provan A,
  Collins AR, Irvine DS.Publication Clin Sci
  (Lond). 2001 Jun100(6)613-8.
• There is no evidence of increased rates of
  fertility disorders among the Asian population
  due to soy consumption.
• Medical foods with soy deliver 17mg of balanced
  isoflavones.

14
Should soy be used for prostate health?

• Yes. Research shows overwhelming evidence of the
  positive benefits in supporting prostate health
  without adverse effects.
• Peterson G, Barnes S. Genistein and biochanin A
  inhibit the growth of human prostate cancer cells
  but not epidermal growth factor receptor tyrosine
  autophosphorylation. Prostate 199322(4)335-45.
• Geller J, Sionit L, Partido C, et al. Genistein
  inhibits the growth of human-patient BPH and
  prostate cancer in histoculture. Prostate
  199834(2)75-79.
• Barnes S. Effect of genistein on in vitro and in
  vivo models of cancer. J Nutr 1995125(Suppl)777S
  -83S.
• Adlercreutz CH, Goldin BR, Gorbach SL, et al.
  Soybean phytoestrogen intake and cancer risk. J
  Nutr 1995125(3 Suppl)757S-70S.
• Nagata C, Takatsuka N, Shimizu H, Hayashi H,
  Akamatsu T, Murase K. Effect of soymilk
  consumption on serum estrogen and androgen
  concentrations in Japanese men. Cancer Epidemiol
  Biomarkers Prev 200110(3)179-84.
• Habito RC, Montalto J, Leslie E, Ball MJ. Effects
  of replacing meat with soyabean in the diet on
  sex hormone concentrations in healthy adult
  males. Br J Nutr 200084(4)557-63.
• Mitchell JH, Cawood E, Kinniburgh D, Provan A,
  Collins AR, Irvine DS. Effect of a phytoestrogen
  food supplement on reproductive health in normal
  males. Clin Sci 2001100(6)613-18.
• Hussain M et al. Soy isoflavones in the treatment
  of prostate cancer Nutr Cancer 200347(2)111-7.

15
Isnt it better to use a more complete protein?

• Early studies suggested that soy was not a
  complete protein source. These early findings
  have been shown to be inaccurate.
• Soy has the same score as egg white and milk
  protein.
• Protein Digestibility Corrected Amino Acid Score
  (PDCAAS), which has been adopted by both the FDA
  and World Health Organization (WHO)
• Sarwar G, McDonough FE. Evaluation of protein
  digestibility-corrected amino acid score method
  for assessing protein quality of foods. J Assoc
  Off Anal Chem 199073(3)347-56.
• FAO/WHO/UNU Expert Consultation. Energy and
  Protein Requirements. Geneva World Health
  Organization 1985 (WHO technical report, series
  724).
• U.S. Food and Drug Administration. Federal
  Register. 21 CFR, Part 101, et al. Part III. Food
  Labeling, 1991.

16
Does soy inhibit thyroid function?

• Well-designed human clinical studies have
  demonstrated that soy has a minimal effect on
  overall thyroid function in healthy individuals.
• Duncan AM, Underhill KE, Xu X, Lavalleur J,
  Phipps WR, Kurzer MS. Modest hormonal effects of
  soy isoflavones in postmenopausal women. J Clin
  Endocrinol Metab 199984(10)3479-84.
• Persky VW, Turyk ME, Wang L, et al. Effect of soy
  protein on endogenous hormones in postmenopausal
  women. Am J Clin Nutr 200275(1)145-53.
• UltraMeal Medical Food Program Containing soy
  protein (15 grams) with a comprehensive
  vitamin/mineral blend
• Patients using the UltraMeal product had no
  change in their TSH levels after 10 weeks.
  Patients using the popular retail product showed
  a significant elevation (150 above baseline) in
  their TSH levels.
• Bland JS, DiBase F, Ronzio R. Physiological
  effects of a doctor-supervised versus and
  unsupervised over-the-counter weight-loss
  program. J Nutr Med 19923285-93

17
Does soy inhibit thyroid function?

• Amounts greater than 200 mg of isoflavones per
  day may inhibit thyroid hormone synthesis in
  susceptible people. (thyroid issues/low iodine)
• Certain studies suggest that soy and soy
  isoflavones inhibit the production of thyroid
  hormones in individuals with thyroid issues.
• Chang HC, Doerge DR. Dietary genistein
  inactivates rat thyroid peroxidase in vivo
  without an apparent hypothyroid effect. Toxicol
  Appl Pharmacol 2000168(3)244-52.
• Approximately 10 million Americans or 3 of the
  population have thyroid issues.
• Alternatives to soy based medical foods are
  available for these individuals.

18
Isnt soy more allergenic than other proteins?

• Soy proteins tend to be less reactive than many
  other food proteins. In fact, soy has been used
  as an alternative for infants with allergies to
  cows milk.
• Cordle CT. Soy protein allergy incidence and
  relative severity. J Nutr 2004134(5)1213S-19S.
• A meta-analysis of 17 studies of allergy patterns
  of high-risk infants revealed soy allergy
  occurring in 3 to 4 of subjects versus 25 for
  cows milk.
• Cantani A, Lucenti P. Natural history of soy
  allergy and/or intolerance in children, and
  clinical use of soy-protein formulas. Pediatr
  Allergy Immunol 19978(2)59-74.

19
Do I have to use fermented soy products to
achieve therapeutic benefits?

• No. The majority of studies around the world
  show beneficial effects of soy.
• Our research studies confirm those findings for
  areas including
• Blood Sugar
• Body composition
• Preserving muscle mass during weight loss
• Cardiovascular risk reduction

20
The Functional Medicine Research Center

• We are the only company in the professional
  market to operate a patient clinic.
• In 2004-2005 the FMRC conducted over 5,000
  patient visits.
• It allows us to test our products for safety and
  efficacy before they reach your patients.
• Many companies use your patients to test their
  products.

21
UltraGlycemX medical food positively affects
blood sugar

• UltraGlycemX Medical Food
• Contains soy protein (15 grams) with a
  comprehensive vitamin/mineral blend
• Clinically Shown to
• Significantly improve
• fasting and 2-hour postprandial insulin
• Triglycerides and cholesterol levels
• Body composition
• Study lasted 8 weeks and 37 insulin resistant
  patients participated

22
UltraMeal medical food positively affects body
composition

• UltraMeal Medical Food
• Contains soy protein (15 grams) with a
  comprehensive vitamin/mineral blend
• Published Peer Review Study
• A 10 week study with 34 patients showed Patients
  on UltraMeal lost an average of 13 lbs with zero
  muscle lost.
• Compared to a popular retail product in which
  patients lost similar weight but lost 85 of it
  as muscle.
• Bland JS, DiBase F, Ronzio R. Physiological
  effects of a doctor-supervised versus and
  unsupervised over-the-counter weight-loss
  program. J Nutr Med 19923285-93

23
UltraMeal medical food positively affects body
composition

• UltraMeal Medical Food
• Published Peer Reviewed Study
• A University of Oregon study showed significant
  change in body composition over 7 weeks.
• 34 patients lost an average of 14.1 lbs of fat
  while gaining 0.9 lbs of muscle.
• Hackman RM, Ellis BK, Brown RL. Phosphorous
  magnetic resonance spectra and changes in body
  composition during weight loss. J Am Coll Nutr
  1994 13(3)243-250

24
UltraMeal Plus program affects body composition
and cardiovascular health

• UltraMeal Plus Medical Food
• Incorporates soy protein and phytosterols with a
  comprehensive vitamin and mineral blend
• Published Peer Reviewed Study
• 42 post-menopausal women were studied for 12
  weeks and the results showed statistically
  significant improvement in 14 independent
  cardiovascular risk markers
• Lukaczer D, Liska DJ, Lerman RH. et al. Effect of
  a low glycemic index diet with soy protein and
  phytosterols on CVD risk factors in
  postmenopausal women. Nutrition 2006 104-113

25
UltraMeal Plus shows significant changes in key
cardiovascular markers

• Weight -14.8 lbs
• Lean Muscle 2.28 lbs
• Total Cholesterol -16
• LDL Cholesterol -15
• HDL Cholesterol 6
• tChol/HDL -20
• TG/HDL -56
• hsCRP -34
• HA1C -3.4
• Insulin -26

26
We support the use of soy

Due to the large amount of reported safety and efficacy studies.
Its long history of safe consumption by Asian populations.
The FDA health claim regarding soy protein and its potential to reduce the risk of heart disease.
Substantial data regarding the benefits of soy in cardiovascular health, prostate health, menopausal symptom relief, and osteoporosis prevention as well as other important areas.
27
We have options to benefit every type of patient

• Many companies just say why one protein or
  ingredient is better than another.
• Thyriod issues and soy allergy patients
• UltraMeal Whey
• UltraMeal Rice
• UltraClear Medical Food
• UltraClear Plus Medical Food
• UltraInflamX Medical Food
• Breast tissue health options
• Estrium Medical Food
• UltraMeal Whey
• UltraMeal Rice
• UltraClear Medical Food
• UltraClear Plus Medical Food
• UltraInflamX Medical Food

28
Decisions must be based on a balanced review of
research

• Metagenics will always select the best
  ingredients and method of delivery to meet the
  needs of your patients
• Variety of proteins in our medical foods
• Use of powders, tablets, capsules and liquids in
  different products to ensure effectiveness as
  well as improved compliance.

29
At Metagenics, we're in the health business - Not
the pill business

• In the health business, safety and effectiveness
  are top priority because there is a lot riding on
  the quality of the products we make
• Your patients health.
• The success of the nutritional therapy you
  recommend.
• Your credibility as a health professional.

30
Genetic Potential Through Nutrition

• We invest more in research and quality than
  anyone else in our industry.
• Our medical foods are just one example of how we
  distinguish ourselves in this industry.
• Always True to Our MissionSince our inception in
  1983, we have never deviated from our founding
  idea - "the patient's best interests must be
  served."