Innate Immunity

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Innate Immunity

• Hugh B.
• Fackrell

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Innate Immunity

• Assigned Reading
• Content Outline
• Performance Objectives
• Key terms
• Key Concepts
• Short Answer Questions
• Next

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Assigned Readings

• Innate immunity 6-11
• Phagocytic deficiences 507-511
• Complement 348-353
• Lysozyme 8, 10

• Interferon (INF) 460-461, 590-591, 373-375
• Tumour necrosis factor (TNF) 370-375
• NK Cells 387-390
• NK Cells and TNF 391
• Next

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Content Outline

• Definitions
• Exterior Defenses
• Interior Defenses
• Soluble factors
• Lysozyme, interferon, complement
• Cells
• Phagocytes, natural killer cells
• Inflammation
• chemotaxis, diapedisis, phagocytosis
• Next

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Innate Immunity Definition

• AKA non adaptive immunity
• Non specific
• Constant

Those factors that are ALWAYS present to defend
the body against infection
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Adaptive Vs Innate Immunity
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Defensive Barriers

• Anatomic
• Physiologic
• Phagocytic Endocytic
• Inflammatory
• Next

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Exterior Defenses
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Interior Defenses Soluble Factors

• Soluble Factors
• Lysozyme
• Interferon
• Complement
• Cells
• Inflammation
• Next

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Lysozyme
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Lysozyme Molecule
Lysozyme.pdb
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Interferon
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Complement functions
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Interior Defenses Cells

• Soluble Factors
• Cells
• Phagocytes
• Natural killer cells
• Inflammation
• Next

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Phagocytes Distribution
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Monocyte
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Neutrophil
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(No Transcript)
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(No Transcript)
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Null Cell
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Perforin Pores
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Cytotoxic cell Pore formation
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Video of Cytotoxic Lymphocytes
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Interior Defenses Inflammation

• Soluble Factors
• Cells
• Inflammation
• Chemotaxis
• Diapedesis
• Phagocytosis
• Next

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Monocyte Movement
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Leucocyte adherance
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Chemotaxis
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Diapedesis
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Macrophage Pseudopodia
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Neutrophil phagocytosis
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Phagocytosis
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Video of Phagocytosis
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Summary Adaptive vs Innate Immunity
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The End