Pathology MCQ

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Pathology MCQ

• PHASE 1

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• 1.Which of the following appear in the red cells
  of Ivemark syndrome/asplenic individuals?
• Macroovalocytosis
• Basophilic stippling
• Howell-Jolly bodies
• Target cells

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• 2. The life span of platelets in circulation is
  about?
• a. 1 to 3 days
• b.3 to 5 days
• c. 5 to 7 days
• d. 7 to 10 days

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• 3. A 13 yr old child suffered from dysentery one
  week ago, currently complaining of hematuria and
  raised serum creatinine. PBS examination is
  expected to show
• Target cell
• Spherocyte
• Schistocyte
• Bite cell

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• 4. HbC is best illustrated as?
• ?2ß2 3Glu?Lys
• ?2ß2 4Glu?Lys
• ?2ß2 5Glu?Lys
• ?2ß2 6Glu?Lys

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• 5. The 4T s scoring system for pre-test
  probability of HIT includes all except
• a. Thrombocytopenia
• b. Timing of platelet count fall
• c. Thrombosis
• d. Treatment dose

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• 6.In comparison to myeloma,which is more frequent
  in plasma cell leukemia
• Osteolytic lesion
• Bone pain
• Renal failure
• All of the above

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• 7. Leukaemia with t(1517)(q22q12) usually has
  the immunophenotype
• CD13,CD33,CD15,CD117
• CD13,CD33,CD117,HLADR
• CD13,CD33,CD117,cMPO
• CD13,CD33,CD15,cMPO

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8. Match the following with respect to iron
deficiency anaemia

1. Red cell zinc protoporphyrin (ZPP)
2. Serum transferrin receptor
3. Transferrin saturation
4. Hepcidin

• Increases
• 2. Decreases
• 3. Increases
• 4. Decreases

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• 9. Which of the following is safe in therapeutic
  doses in patients with G6PD deficiency
• Primaquine
• Acetaminophen
• Sulfamethoxazole
• Dapsone

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• 10. The affinity of haemoglobin for Oxygen is
  decreased by all except
• Fever
• Alkalosis
• Binding of CO2
• Binding of 2,3-DPG

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• 11. An Increased percentage of HbA2 is expected
  in
• a. athal trait
• b. ßthal trait
• c. dßthal trait
• d. All of the above

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• 12. A 15 yr old child presents with fever and
  generalised petechiae, lab investigation reveal
• Hb 6gm MCV 105fl MCH 30pg
• WBC 1.2 X 109 /L PC 10 X 109 /L
• LYMP- 73, GRAN-25,MID-2
• BM Hypo cellular. What is the most likely
  diagnosis?
• Severe aplastic anemia
• Very severe aplastic anemia
• Nonsevere aplastic anemia
• Hypoplastic MDS

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• 13. All are direct thrombin inhibitors except
• Fondaparinux sodium
• Bivalirudin
• Argatroban
• Lepirudin

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• 14. For the given coagulation work up results
  which is the most probable diagnosis
• BT- 5 min
• PT- 11 sec ( 10 sec)
• APTT- 50sec (32 sec)
• Mixing study with factor IX deficient plasma
  APTT 40 sec
• Hemophilia A
• Hemophilia B
• Hemophilia C
• Factor VIII inhibitor positive

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• 15. Regarding febrile nonhemolytic transfusion
  reaction false is
• More common in multiply transfused patients
• HLA antibodies are most common
• Leucodepletion of blood products is not helpful
• Due to transfusion of cytokines

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• 16. Which is not a GpIIb/IIIa inhibitor
• Abciximab
• Eptifibatide
• Tirofiban
• Argatroban

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• 17.Haemolytic disease of new born(erythroblastosis
  fetalis ) is an example of
• Type I hypersenstivity
• Type II hypersenstivity
• Type III hypersenstivity
• Type IV hypersenstivity

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• 18. Pre-transfusion cross-match is not required
  for
• Cryoprecipitate
• pRBC
• FFP
• Granulocyte tranfusion

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• 19. Neutrophilia is seen in all except
• Leucocyte adhesion defect
• Steroid administration
• Lithium therapy
• Kostmann syndrome

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• 20. Infectious complications of blood transfusion
  may result from all except
• HTLV I
• HTLV II
• West Nile virus
• None of the above

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• 21. Good prognosis ALL
• t(411)
• t(922)
• t(1221)
• t(119)

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• 22. For diagnosis of Smoldering Myeloma, false
  is
• BM plasma cells 10
• Absence of anemia
• Serum monoclonal protein 3g/dl
• None of the above

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• 23. IPSS for MDS includes all except
• Marrow blast
• Karyotype
• Cytopenias
• Age

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• 24. Hairy cell leukaemia , immunophenotype
• Bright CD20,CD10,CD25,CD103
• Dim CD20,CD10,CD25,CD103
• Bright CD20,CD11c,CD25,CD103
• Dim CD20,CD11c,CD25,CD103

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• 25. WHO definition of anaemia in pregnancy
  requires Hb below
• 10g
• 11g
• 12g
• 13g

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• 26. Albino child with repeated infection
• most probable diagnosis
• Grescilli syndrome
• Chediac Higashi syndrome
• Dohle bodies
• Toxic granules

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27.

• Comment on PBS

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28.

• Identify the cell with arrow head
• Gaucher cell
• Mott cell
• Histoplasma inclusion
• Fungal bodies

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29.

• Identify the abnormality in the Karyotype

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• 30.Identify the cytogenetic finding shown in the
  FISH metaphase spread.