The Cell Cycle

1
Lecture 6

• The Cell Cycle

2
G0
RESTRICTIONPOINT
3
G0
Rb
represses gene expression
P
P
Rb
Rb
relieves repression
G1
P
Rb
R
growth factor
G1
S
P
R
Rb
P
activate expression of cyclin D
activate cdk2
P
activate cdk4
Rb
activate expression of cyclin E
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G2
S
M
cyclin B cdk1
cyclin A cdk2
6
Cancer

• uncontrolled cell division
• genetic damage
• not corectable
• specific damage to genes that regulate cell
  division

GF
GF
P
P
P
P
activation of cyclin D expression
cell division
7
Mitosis and Cytokinesis

• mitosis division of the nucleus and its
  chromosomes
• cytokinesis division of the cytoplasm
• RESULT one cell divides into 2 daughter cells

8
Phases of Mitosis

• Prophase
• Prometaphase
• Metaphase
• Anaphase
• Telophase

9
During S phase
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