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Total synthesis of Welwitindolinone Alkaloids

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Total synthesis of Welwitindolinone Alkaloids Guochang Gong Group In 1994, Moore reported the isolation of welwitindolinone alkaloids from a series of marines and ... – PowerPoint PPT presentation

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Title: Total synthesis of Welwitindolinone Alkaloids


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Total synthesis of Welwitindolinone Alkaloids
Guochang Gong Group
2
In 1994, Moore reported the isolation of
welwitindolinone alkaloids from a series of
marines and terrestrial cyanobacteria.
Moore et al, JACS, 1994, 116, 9935-9942
total synthesis of Welwitindolinone A isonitrile
and Fischerindole G,see Baran et al, JACS,
2005,127,15394-15396

Wood et al,
JACS, 2006,128, 1448-1449


JACS, 2008,130,2087-2100
3
Wood, JACS, 1999, 121, 6326-6327
Konopelshi, OL, 2001, 3, 3001-3004
Rawal, OL, 2005, 7, 3421-3424
Simpkins, OL, 2005, 7, 4087-4089
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Funk, OL, 2006, 8, 2643-2645
Garg, OL, 2009, 11, 2349-2351
Martin, OL, 2010, 12, 2492-2495
Rawal, OL, 2011, 13, 3214-3217
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Rawal retrosynthetic analysis
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Zayia, OL, 1999, 1, 989-991
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Buchwald, JACS, 1997, 119, 11108-11109 Hartwig,
JACS, 1997, 119, 12382-12383 Buchwald, JACS,
1998, 120,1918-1919 Hartwig, JACS, 1999, 121,
1473-1478
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Rawal et al, JACS, 2011, 133, 5798-5801
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Ryu, TL, 1993, 34, 8283-8284 Kim, TL, 1997, 38,
1597-1598
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Mukaiyama et al, Bull. Chem. Soc. Jpn. 1965, 38,
858-859
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Rawal retrosynthetic analysis
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Chem. Phram. Bull. 1963, 684-685 Chem. Phram.
Bull. 1963, 1413-1417
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Rawal, JACS, 2012, 134, 1392-1395
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Garg retrosynthetic analysis
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Cas2240-16-8 25mL 556
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Chem.pharm.bull.1994, 42, 1393-1398 JOC. 1978,
43, 2057-2059
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Garg et al, JACS, 2011, 133, 15797-15799
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Garg et al, JACS, 2012, 134, 1396-1399
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