Title: Total synthesis of Welwitindolinone Alkaloids
1Total synthesis of Welwitindolinone Alkaloids
Guochang Gong Group
2In 1994, Moore reported the isolation of
welwitindolinone alkaloids from a series of
marines and terrestrial cyanobacteria.
Moore et al, JACS, 1994, 116, 9935-9942
total synthesis of Welwitindolinone A isonitrile
and Fischerindole G,see Baran et al, JACS,
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Wood et al,
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Rawal, OL, 2005, 7, 3421-3424
Simpkins, OL, 2005, 7, 4087-4089
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Garg, OL, 2009, 11, 2349-2351
Martin, OL, 2010, 12, 2492-2495
Rawal, OL, 2011, 13, 3214-3217
5Rawal retrosynthetic analysis
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8Zayia, OL, 1999, 1, 989-991
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10Buchwald, JACS, 1997, 119, 11108-11109 Hartwig,
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12Ryu, TL, 1993, 34, 8283-8284 Kim, TL, 1997, 38,
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13Mukaiyama et al, Bull. Chem. Soc. Jpn. 1965, 38,
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14Rawal retrosynthetic analysis
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16Chem. Phram. Bull. 1963, 684-685 Chem. Phram.
Bull. 1963, 1413-1417
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18Rawal, JACS, 2012, 134, 1392-1395
19Garg retrosynthetic analysis
20Cas2240-16-8 25mL 556
21Chem.pharm.bull.1994, 42, 1393-1398 JOC. 1978,
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23Garg et al, JACS, 2011, 133, 15797-15799
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25Garg et al, JACS, 2012, 134, 1396-1399