Th1/Th2 and Diseases

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Th1/Th2 cell and Diseases
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catalogue

• Source
• Mechanism
• Function
• Diseases (IDDM)
• Therapy
• prospect

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Source

• Helper T cells are found in two distinct cell
  types,Th1 and Th2,distinguished by the cytokines
  they produce and the immune responses they are
  involved in

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Mechanism
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CKs secreted by Th1

• IFN-?
• TNF- ß
• IL-8
• other Chemokines

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Function

• CKs secreted by Th1 can activate and attract
  macrophage to the inflammatory location.
• IFN-? inhibits the proliferation of Th2

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CKs secreted by Th2

• IL-4
• IL-5
• IL-6
• IL-10
• IL-13
• IL-12

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Function

• CKs secreted by Th2 play an important role in
  activation,differentiation,proliferation of B
  lymphocyte.
• IL-12 promoting activation of Th1.
• IL-10 inhibites Th1 secreting IFN-?.

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Diseases

• Autoimmune Diseases

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Th1 predominant response diseases

• Insulin dependent diabetes mellitus(IDDM)
• Theumatoid arthritis
• Helicobacter pylori(HP) infection

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Th2 predominant response diseases

• Systemic lupus eryhematosus
• Metal ion induced autoimmune diseases

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Rheumatoid arthritis
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Systemic lupus eryhematosus(SLE)
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Therapy

• Anti-Th1 type cytokine therapy
• Anti-Th2 type cytokine therapy
• Other therapy for Th1/Th2 cytokine balance

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Anti-Th1 type cytokines therapy and mechanism
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Mechanism of insulin dependent diabetes mellitus

• Pancreatic islet ßcell destroy insulin
  produced decrease
• DDM is mediated by Th1cell ,which produce large
  amount of IFN-?.it is imoportant in leading to
  diabetes

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therapy

• Inject IFN-? monoclonal antibody can turn Th1 to
  Th2,then cytokines L-4,L-10 expression increase
  to prevent diabetes

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Th2 type cytokines therapy and mechanism
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• 1.downstream APC
• 2. inhibit Th1 proliferation
• 3.inhibit L-1,TNF-2 and other
• cytokines(L-6,L-8) produced
• 4.inhibit matrix metal protein
• produce

L-4,L-10
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Prevent diabetes of NOD mice

• I-A27allelic gene56,57 mutation produce Th2
  cell of pancretic islet ß cell antigen
  specificity T cell no response prevent
  the disease

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Other therapy for Th1/Th2 cytokine balance

• (1)Mucosa tolerance
• The TCR/CD3 complex of Th cell recognize
  MHC-peptide complex of APC,change TCR?antigen
  peptide and MHC
• (2)Nirogen monoxide(NO)
• downstream Th1cell and upstream Th2 cell
• decrease the apoptosis of Th2 cell

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Prospect

• Regulate the ratio of Th1 and Th2 by medicine,we
  can cure some diseases without clearly known
  mechanisms.For exampleSLE
• With the development of the immunology,we all
  expected
• these methods can be used to clinic ,
• then these diseases will be cured.

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Thanks