Thermo Scientific Konelab PRIME 60 and Konelab PRIME 30

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Thermo Scientific Konelab PRIME 60 and Konelab
PRIME 30
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Fully automated clinical chemistry systems

• For medium sized laboratories as a stand-alone
  instrument
• For high volume testing as a part of automated
  workcell

Konelab PRIME 60 Capacity up to 600 tests/hour
depending on workload
Konelab PRIME 30 Capacity up to 300 tests/hour
depending on workload
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WORKCELL Automation

• Single entry point without pre-sorting
• Minimizes the need of aliquots
• Workload balancing
• Centralized control over the system

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Continuously expanding test range

• Over 80 carefully validated methods for
• Enzymes
• Substrates
• Electrolytes
• Specific proteins
• Drugs of Abuse Tests
• Therapeutic Drug Monitoring
• CE marked applications can be complemented with
  user-definable tests

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Product overview

• Continuous access to samples, reagents and
  cuvettes
• On-board capacity of
• 84 routine samples, 6 STAT samples
• 39 fixed calibrator control samples
• 45 reagents in the refrigerated disk
• 600 cuvette storage positions in PRIME 30,2100
  in PRIME 60
• ISE option K, Na, Cl-,
• also Li and Ca2 as optional extra
• Interface to a sample track system

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Operational efficiency

• Automated sample pretreatment feature
• Automatic sample clot detection
• Versatile dilution features
• Pre-dilution possibility
• Post-dilution with both high and low secondary
  dilution ratios
• Calibrator set made automatically from one stock
  calibrator for most specific proteins
• Different sample types can be analysed at the
  same time
• Important in drug monitoring and therapeutic
  control
• Reflex testing
• Saves time and money when finding out the
  specific test to be run

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Productive, accurate analysis

• User-safe and contamination free measurement
• Proven, unique, single use 12-cell cuvette
• Cost-effective due to low reaction volume
• Only 100 to 250 ?l
• Typically 120 - 200 ?l
• Flexibility and long walk-away time
• Cuvette storage enables up to 4 hours walk-away
  time
• Continuous loading access without interrupting
  testing

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Advanced design to facilitate routine work

• Integrated workstation with touch screen
• Enables a working posture with less physical
  strain
• Ideal for limited space
• Intuitive graphical user-interface
• Provides fast guidance
• Makes the analyser easy to use
• Available in more than 15 language versions

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Safe sample handling

• Error free sample handling
• Automatic sample identification, direct barcode
  reading and cup/ tube recognition
• Bidirectional LIS interface for quick data
  transfer
• Sample tubes
• 5, 7 and 10 ml tubes
• 0.5 and 2 ml sample cups
• Calibrators and controls
• Cooled positions
• Possibility to load also into segments

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Automated sample pretreatment

• Saves the operator time, e.g. by automating
  hemolyzation in HbA1c measurement
• Improves quality by minimizing operator variation
• Dedicated sample segment for whole blood samples
• For one segment hemolyzation takes about 10 min,
  total turnaround time about 30 min

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KUSTI - optional module for point-in-space
dispensing

• Making automatically an aliquot from the primary
  sample
• Equipped with a 92-positions segment
• While part of automated workcell requested tests
  processed autonomously
• Sample is sent further to the next analyzer
• Minimizing delays on the sample conveyor
• Manual sample loading using segments possible at
  the same time

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Automatic clot detection

• To secure result integrity
• Based on pressure differential technology
• Both in sample and KUSTI dispensers
• The pressure system is calibrated
• By making a series of air aspirations, takes
  appr. 5 seconds, no extra solutions needed
• At start up with sample dispenser
• At every water wash with KUSTI
• Operator is alarmed about clot
• All requests are cancelled for that sample
• Extra wash is performed for needles

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Clot detection in sample dispenser

• Pressure signals of succesful aspirations on
  sample dispenser
• The pressure dives in an aspiration and returns
  through a maximum to the rest level

• The clot message is sent if in aspiration
  maximum fails to reach the rest level or if the
  end pressure of the curve remains too far below
  the rest level

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Clot detection in KUSTI dispenser

• Pressure signals of a succesful aspiration
• In each sub-aspiration the pressure signal dives
  to a certain depth, but returns to the rest level
  between aspirations

• The clot message is sent if in aspiration the
  pressure dives deeper than in a successful
  aspiration

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Convenient reagent handling

• Continuous monitoring possibility
• Flagging of expired reagents
• Determination of vial volume
• Estimation of reagent sufficiency
• Automatic bottle change-over increases the
  walk-away time
• Possibility to run QC with every new bottle
• Used reagent lots can be archived

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Simultaneous electrolyte measurement

• Direct measurement method used in Konelab
• Generally considered the most accurate ISE method
• Serum, plasma and urine samples
• Direct or by manually pre-diluted urine sample
• Micro volume electrodes for even smaller sample
  volumes
• Sample volume of only 50 ?l is sufficient for
  Na, K and Cl-
• Additionally 6 ?l if Li, Ca 2 or pH is required
• Maintenance-free electrodes
• Delivered ready-to-use

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Proactive support

• Minimal user maintenance tasks
• About 5 min daily
• Start up and Stand by procedures
• Maintenance contracts
• 6 and 12 months programs

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Proven technology and experience

• Konelab analyzers are supported with
• Customized installation
• Product training
• Product Application support
• After-sales support
• Maintenance contracts
• Technical service

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Confirmed quality

• Quality system is certified according to the ISO
  90012000 standard extended with the EN ISO
  134852003
• Konelab Analyzer systems comply with the
  requirements of the In Vitro Diagnostic Medical
  Device Directive (IVDMDD)

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Key benefits of Konelab analyzers

• Easy to use
• Clearly laid out, simple to navigate user
  interface
• Automation and analyst efficiency
• Once loaded, the analyzer will run without the
  assistance of the analyst
• Automatic dilution of an over range sample
• Automated sample pretreatment feature
• Reflex test possibility
• Clot detection
• Different types of samples can be analysed at the
  same time
• Important in drug monitoring and therapeutic
  control
• Productivity
• Low reagent volumes -gt low cost per test,
  important in expensive tests
• Quick daily start up
• Minimal maintenance
• User-safe and contamination free analysis
• Disposable cuvettes

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Key benefits of Konelab analyzers

• Carefully selected methods and applications
• Over 150 CE-marked reagents
• Optimized kits serve laboratories of all sizes
• Liquid stable and ready for use
• System-specific multi-calibrators and controls
• Flexible software
• Easy method set-up
• Special applications to be validated by the
  customer or distributor
• Direct electrolyte measurement
• The most accurate ISE method
• Maintenance-free electrodes delivered
  ready-to-use
• Full application and technical support

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One reagent line to be used in all Konelab
analyzers

• Amphetamine
• Barbiturates
• Benzodiazepines
• Cannabinoids
• Cocaine Metabolite
• Opiates
• Cotinine
• Ethyl Alcohol
• Methadone
• Propoxyphene
• Carbamazepine
• Phenobarbital
• Phenytoin
• Theophylline
• Valproic Acid
• Lithium

• Albumin
• Antistreptolysin O
• ? -1-Antitrypsin
• Apolipoprotein A1 and B
• Ceruloplasmin
• Complement C3 and C4
• C-reactive protein
• Cystatin C
• High Sensitive CRP
• HbA1c
• Haptoglobin
• IgA, G and M
• Lipoprotein (a)
• Microalbuminuria
• Myoglobin
• Orosomucoid
• Prealbumin
• Rheumatoid factors

• Albumin ACP
• Total and Direct Bilirubin ALP
• Carbon Dioxide ALT/GPT
• Calcium AST/GOT
• Cholesterol Amylase
• HDL and LDL Cholesterol Cholinesterase
• Creatinine Dibucaine
• Glucose CK
• Iron CK-MB
• Magnesium Gamma-GT
• Phosphorus ?-HBDH
• Total Protein LDH
• Triglycerides Lipase
• U/CSF Protein
• Urea
• Uric Acid Na, K, Cl
• Ca, pH

Enzymes
Substrates
DoA (DAT)
Specific Proteins
TDM
Electrolytes
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Konelab PRIME 60 and PRIME 30

• Operational efficiency and
• accurate results!