The Chain of Logic - PowerPoint PPT Presentation

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The Chain of Logic

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Title: Treatment Options for Glioblastoma Multiforme Author: Bruce H Verkruyse JR Last modified by: rsilvetz Created Date: 3/13/2003 1:47:39 AM Document presentation ... – PowerPoint PPT presentation

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Title: The Chain of Logic


1
The Chain of Logic
  • WHEN a naturally induced vaccine occurs, the
    response is powerful, immediate and of
    therapeutic value to eradication in some cases
    we call these cases spontaneous remissions
  • Extensive circumstantial evidence supports this
    thought
  • There are soluble inhibitors of the immune
    response
  • These inhibitors corrupt the natural endogenous
    anti-cancer vaccine process

2
Local Immunosuppression
Prostate Cancer
Normal
Breast Cancer
Visualization of tumors and metastases in live
animals with bacteria and vaccinia virus encoding
light-emitting Proteins Yong A Yu 1 '3 ,
Shahrokh Shabahang l , Tatyana M Timiryasova2 '3
, Qian Zhang3, Richard Beltz l, Ivaylo Gentschev4
, Werner Goebel 4 Aladar A Szalay 1,4,5
3
Known Clinical Impact ofsTNFr Removal Therapy
  • 6 of 16 patients had greater than 50 tumor
    reduction using an ultrapheresis (membrane-based
    separation) procedure
  • Lentz 1989
  • 5 of 9 late-stage breast cancer patient had
    measurable response with 2 full remissions
  • Lentz 1997
  • Presently in clinical trial in Germany
  • Biopheresis Gmbh, 2009

4
A Different Philosophy
Drug-based Tx Revealtm Technology
Supraphysiologic levels Physiologic levels
Overrides a physiologic mechanism Restoration of homeostasis
Unintended side-effects Limited side-effects
Non-invasive Minimally Invasive
Many drugs liver/kidney toxic No sustainable organ toxicity
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