BASIC AND CLINICAL RESEARCH LINKS

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BASIC AND CLINICAL RESEARCH LINKS

• Romulo S. de Villa, MD, PhD
• Molecular Nutritional Oncologist
• Professor of Biochemistry Nutrition, FEU-NRMF
• Molecular Biology Biotechnology Consultant

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Overview of Medical Research (Basic Clinical)

• A Scientific Investigation to
• understand the disease process
• develop new and improve existing
• diagnostic tools
• (clinical testing for validity, accuracy
  precision)
• treatment (prophylactic therapeutic)
• (clinical testing for )
• Understand the disease process by observing
• patient (clinical community)
• tissue laboratory
• cellular laboratory
• molecular laboratory

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Understand Disease Mechanism

• Basic science will develop
• tools of diagnosis
• agents for treatment

• Clinical medicine will test
• tools of diagnosis
• agents for treatment

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Understanding the Disease Process

• Epidemiologic identification of causative agent
  or factor and
• Critical analysis of clinical course
• Biochemical and Physiologic Mechanisms of the
  disease at the following levels
• tissue
• cellular
• molecular

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Developing and ImprovingDiagnostic Tools

• Developing laboratory procedures
• detect the difference in a sick individual
• indicated by results of
• biochemical and physiologic investigation of
  disease mechanism
• Improving laboratory procedures
• utilize new more sensitive, more specific
  technologies
• (Clinical Testing to determine accuracy)

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Developing and ImprovingTreatment

• Developing agents and procedures that
• reduce the risk of developing the disease
• modify or affect biochemical and physiologic
  mechanisms of the disease that will
• diminish clinical manifestations
• prevent recurrence
• reduce risk of death from the disease
• (Clinical/Community Trial to determine
  effectiveness)

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Thank You !