structure of Aggrecan aggregate

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structure of Aggrecan aggregate
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Collagen fibril embedded in proteoglycan molecules
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Fibroblast surrounded by collagen fibrils
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Collagen fibrils in tadpole skin
This arrangement is also found in bone and the
cornea
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Elastic fibers in a dogs aorta
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Each elastin protein in the network can expand
and contract as a coil
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Fibronectin is an extracellular protein that
helps cells attach to the matrix
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Connective tissue underlying the epithelium
contains a variety of cells and extracellular
matrix components
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A model of the basal lamina
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basal lamina in the cornea of a chicks embryo
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Cross Section of Kidney
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Filtration is one step in urine formation
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Structure of Nephrons
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Inside Bowmans Capsule
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Basal Lamina plays an important role in filtration
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extracellular matrix can propagate order within a
tissue
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Proteases bound to surface receptors are needed
to crawl through basal lamina
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Melanoma cells with low filamin levels crawl
poorly and tend not to metastasize
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Integrin is a transmembrane heterodimer
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Cells can regulate the activity of their integrins
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Focal Adhesion Kinase deficient fibroblasts have
more focal adhesions and can not spread
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Matrix dependent cell survival in embryonic
development
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Signaling Pathways in Cancer