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Nelson R.G. et al., Diabetes Care,13,836,1990.
7
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J-DOIT2
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HbA1C
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4069?
3064?
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C-Reactive Protein
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Target Organs ????(???????)
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????? COX?? (????) 7?a) ????710?(??????), T1/20.40.13?
????? TXA2???? 2?b) ????12(100mg)24(300mg)?, ???TM1?24(300mg)????, T1/21.351.36?
??????? 1?b) T1/22.40.4?
?????? PLA2???? 1?b) T1/2?4?
??????? ??? ?????? ???? (????) 710?d) ????710?(??????), T1/26.601.85?,MRT31.841.42?,?24???????
?? ?????? AC???1) 1014?a) ????810?(??????), T1/21.580.031.610.04?
?????? ???????3) 1?c) ????3??(3040µg/?),T1/27?,20µg/????????????????
?????? ????? 1?b) ????68??, T1/21.11?
???????4) 2?c) ?????48??(?????) T1/22.30.6?(Cap),2.20.8?(Tab)
???????4) ???PDE?? ?? 2?c) ?????48??(?????) T1/22.30.6?(Cap),2.20.8?(Tab)
??????? ???PDE?? ?? 2?b) ????48??, T1/2(ß)18?
?????? ???PDE?? ?? 3?b) T1/212?
?? ???????? ?????(5HT2) ??????? 1?b) ????12??, T1/20.69?
??????? ???? ?????(5HT2) ?????? 1?b) T1/21.31.4?
?????? ???? ????K?? ?????? ???? ???5? ???45??????? ????????????e) ????4872??, T1/236.3?
COX??????????,TXA2???????A2,PLA2???????A2,AC??
????????,PDE??????????? ?????????????,a)??????,b
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1) Wahl, M, J. Arch. Intern. Med., 158,
1610-1616, 1998 3) Maeda, Y., et al. Blood
Vessel., 13, 142-145, 1982 4) ???????????,25,1085
-1109,1991
???????,40(3),343-346,2006
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??????????????????????????(??/??????),P329-331,20
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????? ?????? ??????? ??????? EPA ???????? ?????? COX-1?? ADP????? ADP????? PDE3?? ?????????? 5-HT2????? PGI2????? ???? ???? ???? ??? ???? ??? ??? 710? 710? 710? 48?? 710? 24?? 24??
??????Progress in Medicine,26(6),1255-1258,2006
15
Ziffer AM, Scopp IW, Beck J, et al Profound
bleeding after dental extractions during
dicmoral therapy. N Engl J Med 1957256351
???????? 100?? ????? ??????? 1?? ?? 8??
????????????
??? Wahl MJ Arch Inern Med 19981581610 542?
???????? ??5? (?1)?5??4??? (80) ??????
Blacker DJ Neurology 200361964 AF???1,137?
????????/?? ???12? (1.06) ???????
?????????? 3.4 (Arch Neurol 2005621217)
?????? ????? ?? Palareti G Thromb Haemost
199472222
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(2002????????????)

??????????????23? ???(8?) ????(15?) INR 1.20
(0.942.50) 1.50 (1.092.38) NIHSS 19 (122) 3.5
(022) ??????? 100 46.7 mRS?3 71.4 21.4 ??8?
??????4?(50)?????4? ???? 4.5?????????? 7.5?(???)
???2-3?
??4-5?
Yasaka M Thromb Res 2006118290
17
????????????????

• ???????????
• ?????????
• ?????? Evans IL Br J Oral Maxillofac Surg
  200240248
• Sacco R J Thromb Haemost 20064688
• ????? Ardekian L JADA131331-335, 2000
• ????
• ??????? 20062593-98 ? INR 3.0?? ??????
• ??? ??? 200527424-427 ? ????? ??????
• ??? ??? 200654993-1000

18
??????????????????
????????? Evans IL Br J Oral Maxillofac Surg
200240248
???? ???(????????????)???? 20062593-98
INR??????
INR ??? ?? ????? ???? ?? ?? lt 2.0 57 0 0
2.0 - 2.5 44 0 0 2.5 - 3.0 17 0 0 0
Total 118 0 0 5 (4.2)
5 (??????)