Processed Amniotic Membrane Allografts

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• Processed Amniotic Membrane Allografts

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Amniotic Membrane Allografts
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What is Human Amniotic Membrane?

• A unique, avascular membrane separating the
  mother from the fetus.
• Provides an incubating environment promoting
  cellular differentiation.
• Provides an immunological barrier to prevent
  foreign body rejection.

Photo Courtesy of Juan Batlle, M.D.
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Anatomical Profile AM
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Anatomy of the Ocular Surface
(1) Conjunctival Epithelium (2) Corneal
Epithelium (6) Limbus Stem Cells
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History of AM in Ophthalmology

• De Rotth. conjunctival defects (1940).
• Lavery. lime burn of conjunctiva and cornea
  (1946).
• Sorsby et al. caustic soda burns (1947).
• ALLOTRANSPLANTAT late 80s USSR-gtVenezuela, DR
• Batlle and Perdomo. Conjunctival substitute with
  placental allotransplant. Scientific Poster 25.
  American Academy of Ophthalmology meeting.
  Chicago, IL USA. October 1993.
• Kim and Tseng. Transplantation of preserved human
  amniotic membrane for surface reconstruction in
  severely damaged rabbit corneas. Cornea
  14473-84, 1995.

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Surgical Indications AM

• Pterygium Excision
• Corneal Ulcerations/Perforations
• Chemical/Thermal Burns
• Bullous Keratopathy
• Ocular Dermoids/Tumors
• Fornix Reconstruction/Symblepharon
• Stem Cell Transplants

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Pterygium

• A mutated growth on the surface of the eye
• Requires surgical excision and placement of graft

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Corneal Ulcerations/Perforations

• A break or defect in corneal epithelium
• Often secondary to other systemic diseases.

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Chemical/Thermal Burns

• Chemical burns often caused by alkali
• Potentially devastating trauma to surface of the
  eye
• Limbal graft possibly indicated

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Bullous Keratopathy

• Edema of the corneal endothelium
• Very common and usually affects individuals over
  50 years of age.

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Dermoid/Tumor Removal

• Benign congenital tumors containing foreign
  tissue
• Commonly found at the limbus

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Fornix Reconstruction

• Fibrous tract that connects bulbar conj to conj
  of eyelid
• Secondary to other acquired or traumatic
  conditions
• Required reconstruction of ocular surface and
  eyelids

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Surgical Techniques AMT/Pterygium
Photo Courtesy of Juan Batlle, M.D.
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AmbioDry2 Overview

• Tested Safe
• Dehydrated
• Terminally Sterilized
• Strict, quality-controlled protocols
• Device-like quality

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AmbioDry Safe Viable

• Intact epithelial cell layer
• Intact dense connective, basement membrane
• Presence of loose fibroblast network

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AmbioDry Logistical Features

• Storage Room-temp
• No freezer required
• No dry ice shipments
• Simple prep No soaks or rinses
• IOP Customer Service 24 Hrs/7 Days

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AmbioDry Surgical Advantages

• Substrate-free
• Dry-state handling trimming
• Visual orientation identification
• No tears or buttonholes
• Device-like tissue quality

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AmbioDry Configurations

• 1 x 2 cm
• 2 x 3 cm
• 4 x 4 cm

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Reimbursement Codes

• Supply Code V2790
• CPT Code 65780 Ocular surface reconstruction
  amniotic membrane transplantation

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AmbioDry Tisseel

• The sutureless approach to eye surgery.
• Fibrin (biological) adhesive
• Eliminates sutures
• Reduces surgical time
• Improved patient care
• Better healing

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AmbioDry Tisseel Video