Stress

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Stress
? ? Stress
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Stress
??????
?????????
???????, ???????????
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Stress
??? ???? (Basic concepts of stress)
??(Stress)
???(Stressor)
??????(Classification of stress response)
????(Significance of stress)
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Stress
1.??(Stress) ??????????????????????
??? ?????????? Stress is defined as a state
of tension that can lead to disharmony or
threaten the homeostasis of body.
?????? ??????
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Stress
2.???(Stressor)
??????????????????? The stimuli or agents
that induce stress are termed stressor.
Stressor
?????(Physical, chemical, biological)
Cold, heat, toxins, drugs, bacteria.
????(Intrinsic factor of body)
Homeostasis, disease, cancer.
??????(Psychological or socio-cultural)
Threat to self esteem, relationships with other
people.
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Stress
3.??????(Classification of stress response)
Physical, chemical
Stress response
Physical stress
Psychological stress
Psychological or socio-cultural
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Stress
4.??????? (General adaptation syndrome,GAS)
???????????????????????,???? ??????,???????
???????????GAS?
????????????????????
??????,??????????????????
???Alarm stage
??????????????
??????????????,?????????????
???Resistance stage
???Exhaustion stage
????????
?????????????????????????????????
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Stress
????????? (Neuroendocrine responses to
stress)
???????
??-???????????(LC-NE)??
???????
???-??-?????? (HPA)????
????????
Rest hormonal responses to stress
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Stress
?Locus ceruleus - Norepinephrine (LC-NE)
1. LC-NE??????(?????????)
???? ???? ???????(PVN)
??
?????
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Stress
2. ??CNS??(Effects of CNS)
??????????????????? ?????HPA?????
(???????)
3. ?????? (Effects of
peripheral) ??CA(Ad?NE?Dopamine)
??????(???????) (??????????????)
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Stress
4. CA???????? (Functional and
metabolic responses in body)
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Stress
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Stress
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(??????)? ? ? ? ?
??????
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Stress
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Stress
GC?????????????? ???????????????????????
,????????? ??????????????
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Stress
????????? Cell-humour responses to stress
????????,????????????????????????,
??????????(cell stress)??
In responses of cellular-molecular level to
more stressors (mai- nly non-psychogenic
stressors), cell arouse a series of intracellu-
lar signal transduction and activation of
correlative gene and syn- thesize some protective
protein, which mainly are heat shock pro- tein
and acute phase protein.
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Stress
(?????????????????)
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Stress
???????
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Stress
1.????? (Funcation
and classification of HSP) ?????
HSP110?HSP90?HSP70?HSP60????HSP??

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Stress
????HSP ???????????????????????
??,??????????,?????
?????????????
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Stress
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Stress
HSP??? ????????,????????????,??
???????????(???HSP70 )
???Na-K-ATP???? ??HSTF????,??HSTF?????,??HSP
???
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Stress
3.??HSP????(Factor of induced HSP production )
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Stress
??? ?????????????
Effects of stress on the body
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Stress
1. ????(Effects on metabolism) ????
????????????????
???????
????????
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Change of cardiovascular system Change of
gastrointestinal
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Stress
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Stress
Change of blood ???? ??????
????????????? ???????DIC??
Change of kidney and procreation
??????,????? ???????,?????????
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Stress
??? ?????(Stress and disease)
??????(Stress ulcer) 1.Concept
????????????????????????,
????????????????
Stress ulcer is the term given to mucosal
damage or lesions of the esophagus, sto-mach or
duodenum in critically ill or stress- ed
otherwise healthy patients.
???????????(???? ?,?????????)?
???????????,???? ?????????
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Stress
2.???? ????(??????????????)
??-????? () ? ?????????????

???? ??????HCO3-????
????????? ???????
H????? ??H??????
H??????
????? H?????????,????????????????
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Stress
????????? GC???????????,?????????
??? ??,????H?????????? ????
??????? ?????????? ????
????????? ????????????

????????????
?????
?????
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Stress
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Stress
?GC???????? ???WBC???????M??
Ag?????? ???LC ?DNA???????
??LC??? ?????? ???????????????
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Stress
APs????? APs????? ?????????IC ?? ???????

TNF-a?IL-1?IL-6? ?????????? ? CRH
IL-1 ?
GC??IL-1?TNF-a ?? ? GC
?????????IL-1 ? ?????a-MSH ???? ??????????????
TNF-a?IL-1?IL-6?
?????APs (VEC?Mo?fibroblast)
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???
1.?????????? 2.??CA?GC?????????????? ?
3.?????????????? 4.?????????????? 5.????????