MEDICINE AND HEALTH IN THE TROPICS Plenary Session 3 - PowerPoint PPT Presentation

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Title: MEDICINE AND HEALTH IN THE TROPICS Plenary Session 3


1
MEDICINE AND HEALTH IN THE TROPICSPlenary
Session 3 The Pharmaceutical Industrys RD
Drive and the issue of Tropical diseases 13
of September 2005
  • Dr Pierre Le Sourd
  • Leem President

2
The issue of Tropical Diseases
  • Definition
  •  Neglected infectious diseases that
    disproportionately affect poor and marginalized
    populations (TDR Special Program for Research
    and Training in Tropical Diseases)
  • Current disease portfolio

TDR Disease Category 1  Emerging or
uncontrolled disease  2  Control strategy
available, but disease burden persists  3
 Control strategy effective / Elimination
planned 
 Source World Health Report, 2004 DALYs -
Disability Adjusted Life Years (the number of
healthy years of life lost due to premature death
and disability)
3
What is the Pharmaceutical Industry doing about
it ??Drug Companies part of the solution
instead of the issue
4
Medicines existbut dont reach the patients in
need
  • Most essential medicines are off-patent and
    inexpensivehowever over 50 of populations in
    Least Developed Countries lack regular access to
    these products

Source IFPMA, Septembre 2004
5
What are the real barriers ?
  • Poverty
  • Lack of public health infrastructure
  • Lack of human resources
  • Lack of manufacturing capability
  • High tariffs on medicines
  • Political denial

6
Successful interventions supported by Drug
Companies (1)
  • In last decade, global companies have become
    critical contributors to numerous programs and
    initiatives targeting health needs of the poor
  • In 2003, the value of donations by major
    companies matched the US AID Global Budget for
    Health
  • 3,7 billion over last 5 years

7
Successful interventions supported by Drug
Companies (2)
  • Examples of concrete actions
  • Malaria
  • In 2001, Novartis formed a partnership with WHO
    to provide Coartem at no profit in developing
    countries
  • Sanofi-Aventis launched a Specific Program
     Impact Malaria  to develop new treatments, new
    therapeutic strategies, educational campaign and
    to provide drugs at price,  not loss, not
    profit 
  • Achievements Pilot projects in South Africa
    resulted with outstanding health outcomes
  • Malaria cases reduced by 86
  • Hospital admissions for malaria reduced by 82
  • Malaria deaths decreased by 87
  • Tuberculosis
  • In South Africa, a huge involvement of
    Sanofi-Aventis
  • Rifafour a combination of 4 medicines
    commercialized to enable better compliance
  • A specific training program of 15 million
    developed DOT Supporters (DOT Directly
    Observed Treatment) for Health agents
  • Ambitions
  • Building of 9 Training centers
  • 100,000 Health agents trained

8
Successful interventions supported by Drug
Companies (3)
  • Examples of concrete actions
  • Leishmaniasis
  • Ampules of Glucantime (Sanofi-Aventis) provided
    at no profit
  • Onchocerciasis
  • 40 million doses of Mectizan (Merck) donated
    annually in 34 countries
  • Trachoma
  • 16 million treatments donated in 11 countries
  • More than 80 million of Zithromax (Pfizer)
    donated
  • Leprosy
  • 35 million donated in multi-drug treatment
    (Novartis)
  • Achievements
  • About 13 million people cured over the past 15
    years, while some 2-3 million people have been
    protected from developing deformities
  • Lymphatic Filariasis
  • 6 billion treatments of albendazole (GSK) planned
    to be donated
  • 20 million treatments of Mectizan (Merck) donated
  • Achievements
  • 80 million people have received treatment

9
Successful interventions supported by Drug
Companies (4)
  • HIV/AIDS reference
  • To increase access to ARVs in developing
    countries, a huge involvement of the
    Pharmaceutical Industry
  • 564 million in 2002
  • Involvement in International Programs
  • ONUSIDA
  • ACCESS thanks to significant price discounts,
    more than 330,000 patients in developing
    countries received ARVs by the end of September
    2004
  • Pharmaceutical Initiatives
  • Determine Donation Program (Abott), Secure the
    Future (BMS), African Comprehensive HIV/Aids
    Partnership (MerckCo), International HIV/Aids
    Health Literacy Grants Program (Pfizer)
  • Health agents Training, equipments supply,
    prevention technical aids, health education

10
New or improved treatments needed
Source IFPMA, Septembre 2004
11
Drug resistance is widespreadthe example of
Malaria
12
What about new drugs and vaccines ? (1)
  • Quantum leap in Research is coming
  • RD is at a crossroad
  • Development of Biotech Products
  • 2003 40 of New Molecular Entities
  • 2010 around 100 New Molecular Entities expected
  • could deliver major breakthroughs
  • leading to new hope for Tropical Diseases

13
What about new drugs and vaccines ? (2)
  • New dynamics in RD for Neglected Diseases
  • Establishment of dedicated research centers by
    major companies and increasing not-for-profit
    approach to RD for neglected diseases
  • Creation of a RD efforts database of IFPMA
    members
  • Growing number of product development public
    private partnerships (PPPs)
  • Proliferation of RD players, including public
    research institutes, academia, major pharma
    companies, small specialized biopharmaceutical
    companies from developed and developing
    countries, etc.

14
Establishment ofDedicated Research Centers
Source IFPMA, Septembre 2004
15
Creation of a RD efforts database
  • In September 2005, launch of a database
    collecting all the health initiatives involving
    the pharmaceutical industry to benefit the
    Developing countries
  • A comprehensive list of both RD and Access
    Initiatives
  • Accessible on the Internet (via the IFPMA
    website) by the general public
  • Create an overall vision for industry activities
    in addressing developing countries needs
  • Build a central depositary used to create new
    collaborations and partnerships

16
Public-Private Partnerships development (1)
  • TDR The Special Program for Research and
    Training in Tropical Diseases - and its Industry
    Partner a long and fruitful collaboration

17
Public-Private Partnerships development (2)
  • Examples of Product Development PPPs for
    Neglected diseases

Source IFPMA, Septembre 2004
18
(No Transcript)
19
FAC Project an innovative partnership against
Malaria
  • For Malaria, new medicine needed to adress drug
    resistance
  • WHO recommands the development of 4 Artemisine
    Combination Therapies (ACT)
  • But, 2 combinations needed a new fixed-dose
    combination
  • FAC Project
  • A scientific partnership, coordinated by DNDi, to
    develop fixed-dose combination of
    Artesunate/Amodiaquine (AS/AQ) and
    Artesunate/Mefloquine (AS/MQ)
  • A public-private Innovative partnership
    Sanofi-Aventis DNDi
  • In 2006, a new medicine available
  • Easy to use for adults and children
  • Less expensive Target price 1
  • Off patent
  • WHO estimations 50 to 100 million of people
    could received this treatement

20
Results a growing RD pipeline
Source IFPMA, Septembre 2004
21
Conclusions
  • Public-private partnerships prove to offer the
    most effective solution
  • Pharmaceutical companies increasing its
    commitment in
  • Developing dedicated RD projects
  • Establishing many health partnerships
  • Bringing critical resources (products, money,
    people)
  • Contributing in valuable cross-country experience
    and expertise in health care delivery
  • Introducing a private sector management
    philosophy that helps achieve needed results
  • Significant and promising global awareness

22
Conclusions
  • Therefore, any successful initiatives must
    include
  • Political will
  • Partners
  • Infrastructure to get the medicines to patients
  • Physicians training and patient education
  • Proper diagnosis dispensing
  • Quality control
  • Proper dispensing
  • Monitoring of outcomes
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