(?)?????(Cellulose Acetate)

1
??? ?????????? ???????
(?)?????(Cellulose Acetate)
(1)??
2
(2)??
????????,?????????,??????????????????????????????
?
?????????,???????
??????pH?????,???????????,????,???????
(3)????????????(??????),???????(??????)?
?????????????,?????????????????,???????????????
3
(?)?????(Cellulose Acetate Phthalate)
1???
????1726,????3036? ?????1??????,??????????????
?????
2???
(1)???????????????,????????,????pH6.0?????????,??
????????????????,
4
(2)????????,?????????
(3)????????,?????,?????????????? CAP
??????????,???????????????????
(4)???HIV??????????
3?????????(??????)??????
5
???????
(?)??????? (Carboxymethylcellulose
Sodium)???CMCNa?CMCCa
1???
6
2???
(1)??????????????,????????????????,??????????????
???????????,0.52???,??0.7???
(2)?????,?????????????,????????????????,???????pH
gt10?pHlt5??????,pHlt2,????????gt0.8,???????? (3)???
?????????????
7
??CMCNa????,??????????????,?????????????? CMCCa?
???CMCNa??,?????,????,??????
8
3??? CMCNa???????????????????????????????????????
???????,??????????????,???????? ??????????????????
????? ????????????????,???????????(???????????????
?????????)????
??CMCNa????? CMCCa??CMCNa??????,???????????? ???
???????????????? ????????????????
9
(?)?????(Methyl Cellulose)
1???
R-H?-CH3
10
2???
(1)????27.531.5,???1.52.2,???501500?
(2)???????????,????1.261.31,??280300?
(3)?????????????????????????????????????????????
????????????,????2???????????
11
(4)??????,??????,????????????,???????
(5)??????,pH?2-12??????,?????????,?????????????
(6)????????,????,???????
3??? ?????????????????????????
12
(?)?????(Ethyl Cellulose)
1???
R-H?-CH2CH3
13
2???
(1)???????????????,??????
(2)??????????????????? ?????lt46.5,??????????????
??? ?????gt46.5,?????????????????????
14
(3)????????,???????,????????????
3???
??????????????,????????????????????????????
??????????????????
15
(?)??????(Hydroxyethyl Cellulose)
1???
2???
(1)???????????????????????,??????????(???????????
????),????????????????????
16
(2)??????????????????????????????????????
(3)??????????????,????????????????,???????????pH?
212???,??,??????
(4)????????????????
17
3???
???????????????? ?????????????????????????
??,??????????,???????????
18
(?)????????????????(HPC,L-HPC) ????????????????.
1???
HPC??????53.477.8,L-HPC???516
19
2???
(1)???HPC?????????????????????????????,??????????
?
(2)????????38?????,????,?4045????????,??????
(3)????????
20
(4)???????,??????????????(?pH)???????????????????
?????,????????????????
(5)L-HPC??????????????,???????,?????????????? ???
????????,???????,?????
21
3???
??????????????, ???????????????????????????
???????????,?????????
L-HPC????????????
22
(?)??????(HPMC) ?????????????????
1???
??????1.02.0,???????????0.10.34
23
2???
(1)??????????????????? ?????????,??????? ????????
??????????,????????????????? ??????? (2)??????,??
????,?????????????????????
(3)???????????????????????????????????????????,?
??????????????? (4)????pH?212??????????????,???
??????
24
(5)????????? ???????????,??????,??????????????????
? (6)???
3??? ????????????????????????????????????????,????
???????????????? ?????????????????????????????,???
?,?????
25
????????
(?)??????????(HPMCP) 1.?? ??????????????,??????
????????? 2.?? ???????????????
???????????? ????????????
???? 3.?? HPMCP?????????????????,?????,???????????
????????? ??????,?????????????,???????????????????
??????
26

• (?)???????????????(HPMCAS)
• 1.??
• ???????????,??????????????
• 2.??
• ?????????????,????????????
• ???
• ???200?????,?CAP?HPMCP??
• 3.??
• ???????????????????????????
• ???????????????,????????????????????????