Human Chorionic Gonadotropin (hCG):

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• Human Chorionic Gonadotropin (hCG)
• The Story Of Pregnancy Hormone

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General introduction

• ?????????
• Human Chorionic Gonadotropin (hCG)
• MeSH
• Chorionic Gonadotropin
• Placental Hormones
• Pregnancy Proteins

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General introduction

• hCG????????????,????????????????hCG??????,????????
  ????,????????,?????????hCG
• ???hCG???????????????,???????????hCG???????????

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General introduction

• ??LH????,????, ???????,??????
• hCG???????????????(steroidogenesis),??????????????
  (testosterone)
• ?hCG???????6?,?hCG?12-14????
• ?????48-72 h,?????????,?????? 96 h???8 - 10
  w??,???????????

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General introduction

• ?FSH?LH?TSH??,??a?ß????????a?????????????????,????
  ?????,??????ß???
• ?????ß-HCG,?????????

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Key things about hCG levels (1)

• ?hCG??????????? ?????hCG?????????????
• ??????hCG??(5 - 6 ???? )????

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Key things about hCG levels (2)

• ???? ???????(beta hCG)??
• The hCG hormone is measured in milli-international
  units per milliliter (mIU/ml)
• ?????lt 5mIU/ml ??
• gt 25mIU/ml ??????

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Key things about hCG levels (3)

• ??????? 1,000 - 2,000mIU/ml
• ??????????????,???hCG??????,???????????????????
• ???????,?????????????????

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Guideline to hCG levels during pregnancy

• 3 weeks LMP 5 - 50 mIU/ml
• 4 weeks LMP 5 - 426 mIU/ml
• 5 weeks LMP 18 - 7,340 mIU/ml
• 6 weeks LMP 1,080 - 56,500 mIU/ml
• 7 - 8 weeks LMP 7, 650 - 229,000 mIU/ml
• 9 - 12 weeks LMP 25,700 - 288,000 mIU/ml
• 13 - 16 weeks LMP 13,300 - 254,000 mIU/ml
• 17 - 24 weeks LMP 4,060 - 165,400 mIU/ml
• 25 - 40 weeks LMP 3,640 - 117,000 mIU/ml
• Non-pregnant females lt5.0 mIU/ml

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False positive of hCG?

• ?ß-HCG????????????????,?????????,?????
• - ??????????????????hCG??,????????????
• - ???????????????????,????????hCG
• - ??????????,?????????hCG???

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What can a low hCG level mean?

• A low hCG level can indicate
• -????
• -????(????)
• -????
• rechecked within 48-72 hours to see how the level
  is changing.

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What can a high hCG level mean?

• A high hCG level can indicate
• -????
• -???
• -????
• rechecked within 48-72 hours to evaluate changes
  in the level.

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Should hCG level be checked routinely?

• ???????????,????
• ????
• - ????
• - ??(??)
• - ???

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hCG levels after a pregnancy loss?

• ?????????4 - 6 weeks??(lt5.0 mIU/ml)
• ????,??????? (????, ??????, ????,2 weeks)
  ,??????
• ?????? lt5.0 mIU/ml

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?????HCG???(mIU/ml) ?????HCG???(mIU/ml) ?????HCG???(mIU/ml)
????? 12 34 56 78
5 70 66 12.5 19.5
??? 950 260 49 41
95 5750 2450 330 140
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?????HCG??? (mIU/ml) ?????HCG??? (mIU/ml) ?????HCG??? (mIU/ml)
????? 15 610 1115 1620
5 lt12.5 lt12.5 lt12.5 lt12.5
??? 15000 230 92.5 57.5
95 46500 3250 490 205
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Applications

• Prengnancy diagnosis
• Ectopic pregnancy
• Hydatidiform mole
• GTN
• PSTT
• Assistant reproduction
• Contraception

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Others

• ?????4-8?,HCG??2-3d?????
• LMP?7?,???????????????,HCG?20000mU/ml?
• ?9-10???????,??????lt5ng/ml??????(?????????),gt25ng
  /ml?????????

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Others
???????????????? ???????????????? ???????????????? ????????????????
?? ng/ml ng/L  
7 24.5 76.4  
8 28.6 89.2  
912 38 118.6  
1316 45.5 142  
1720 63.3 197.5  
2124 110.9 346  
2534 165.3 514.8  
gt35 202 630  
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Others

• ?8-13?????????,?????????????????(cm)6.5
• ??????2cm?????????,?????5mm????????

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The End

• THANKS FOR YOUR ATTENTION!