TB Wrap-up

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TB Wrap-up

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• 16 ??????? 2550

??. ??.???????? ????????? petchawanp_at_yahoo.com HS
9 QCB, 081 5421054
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• 1/3 ????????????? -gt ??????????????
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• 1.9 ????/?? -gt ?????????????

An Expanded DOTS Framework for Effective
Tuberculosis Control. Stop TB, Communicable
Disease, WHO WHO/CDS/TB/2002.297
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1993
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1990s
MDR-TB
Multi-Drug Resistant Tuberculosis INH Rifampicin

• 2000 275,000 cases
• 2004 425,000 cases
• 2005 460,000 cases, 2/3 -gt Russia, China, India

The Emergence and Impact of Extensively
Drug-Resistant Tuberculosis Christopher J
Lettieri, MD
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2005
XDR-TB
Extensively Drug Resistant Tuberculosis MDRFluoro
quinolone1 injectable SL drugs

• 2 of all cases of culture-positive TB
• CFR 80-100, South Africa 2006 53 -gt 52 cases
  died within 25 d
• WHO 2007 95 millions US

The Emergence and Impact of Extensively
Drug-Resistant Tuberculosis Christopher J
Lettieri, MD
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• ??????????????????
• ??????????? Dx
• ?????????? Rx
• TB, ?????, TB/HIV, MDR
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• ???/????????? ADR
• ???????????? DOT
• ?????? TLTI, TB/HIV collaboration
• ????????????? Cohort analysis