Pathogenesis

1
Pathogenesis
??. ??????? ?????????
2
???????????????????????

• ???????????????????????? 2 ????
• ?????? (upper respiratory tract)
• ???????? ????? ??????????
• ???????? (lower respiratory tract)
• ?????? ????? ???

3
????????????????????

• ?????????????????????????????
• ???? (common cold) ?????????? ?? ????????
• ???????? (pharyngitis)
• ???????????????? (tonsillitis)
• ???????????????????????????????
• ???????????? (bronchitis)
• ????????? (pneumonitis)
• ?????? (pneumonia)

4
Influenza virus

• ??????????????????????
• Family Orthomyxoviridae
• ???????????????? RNA , ?? envelope
• ??????????????????????????????? genetic
  recombination

5

• ???????????????????????????????????????????????
• 1. Type
• 2. ??????????????????????????
  ?????????????????????
• 3. ?????????????????????
• 4. ??????????????????????????????
• 5. ?? ?.?. ???????????????????
• 6. ??????? type A ??????? subtype H, N
• Ex. A/Bangkok/1/79 (H3N2)

6
???????????????????????

• ???????????????????????????????????????????
  ??????????? ??????
• ????????????????????????????????????????????????
  ?????????????????????????
• ??????????? ???????? ???????? ????????
  ??????????????????? ???????? ?????? ????????
  ????????????

7
Rhinovirus

• ???????????????????????? (common cold)
• Family Picornaviridae
• Genus Rhinovirus
• ???????????????? RNA , icosahedral capsid

8
???????????????????????

• ????????????????? ????????????????????????????????
  ???????
• ?????????????????????????????????
• ???????????? ???????? ??? ?????? ????????
• ????????????? ???????????????? ????????????????

9
??????????????????????

• Rotavirus
• Family Reoviridae, Genus Rotavirus
• ???????????????? RNA , icosahedral capsid
• Capsid ???????????? 2 ???? ?????????????????
  (rota)

10
???????????????????????

• ???????????????????????????????? ????????????????
  ?????????????????????????????? ?????????????????
• ??????????????????????????????
• ??????????????????????????????????????
  ????????????????????????? villus
• ??????? ????????????????? ???????????????
  ???????????
• ??????????????????? 2 ???
• ???????????????????????? ?????????????????? ?.?.-
  ?.?.

11
(No Transcript)
12
???????????

• ????? ?????????????????????????????????????
• ????????????????? 2-5 ??? ???????????????
• ??????????????????????????????? (dehydration)
• ???????????????????? electrolyte

13
????????????????????

• ???????? 2 ?????????????????????
• 1. ?????????????? ?????????????????????????????
• ??????????
• - HAV, HEV ?????????????????????????????????
• 2. ???????? ????????????? ??????????????
• ?????????????????
• - HBV, HCV, HDV ???????????????????????? ????????
  ? ???????????

14
Hepatitis A virus (HAV)

• Family Picornaviridae, Genus Hepatovirus
• ???????????????? RNA , icosahedral capsid
• ??????????????????????? ??????????????????????????
  ????????????? ?????????????????????
  ???????????????????????????
• ?????????? 2-4 ???????
• ?????????????????????????? ?????????????????????
  ??????? ???????? ?????????????????? ?????????
  ???????? ??????????????????
• ??????????????? 3-8 ??????? ???????????????????

15
Hepatitis B virus (HBV)

• Family Hepadnaviridae
• Genus Orthohepadnavirus
• ???????????????? DNA , icosahedral capsid
• ?? envelope
• ?????????????????????? hepatitis B surface Ag
  (HBsAg) ?? envelope
• ?????????? nucleocapsid ???????? hepatitis B core
  antigen (HBcAg)
• ???????????????? HBcAg ???????? HBeAg

16
???????????????????????

• ???????????????????? ?????????????????
  ??????????? ???????????????
• ???????????????????????????????
• ????????????? 6 ?????
• ??????????????? 3 ???
• - ???? 42 nm
• (Dane particle)
• HBsAg
• - ???????????????????? 20 nm
• - ?????????????

17
???????????

• ????????????
• ???????????????????????
• ????? ?????????? ???????? ???????????????????
  ????????
• - ???????????????? anti-HBs
• - ????????????????????????????? ????????????????
• ????????????
• ?????? HBsAg ??????? 6 ?????
• - ???????????????????????
• - ?????????????????????????? ?????????

18
(No Transcript)
19
Hepatitis D virus (HDV)

• ???? defective virus
• ???????????????? RNA , capsid ?????????
• ?? envelope ????????? HBV

20
???????????

• ???????? 2 ??????
• Coinfection
• ??????????? HBV ??????? HDV ??????????
• ???????????????????????
• Superinfection
• ??????????? HDV ??????????????? HBV
• ???????????????????????? ????????????????????????
  ?

21
Hepatitis C virus (HCV)

• Family Flaviviridae
• ???????????????? RNA , icosahedral capsid
• ?? envelope
• ???????? HCV gene ?????????????????????????????
• serum ??????????????????????????
• ???? viral RNA
• complementary DNA (cDNA) ???? clone ??
  expression vector

22
(No Transcript)
23

• HCV gene
• Structural gene (1/3-1/4 ??? genome)
• ????? core (nucleocapsid protein), envelope
  protein (E1, E2)
• Nonstructural gene (2/3-3/4 ??? genome)
• ??????????? ??????????????????????????????
• Non-coding region
• 5 , 3 untranslated region ????????????????????
  ?????
• ???????????????????????
• ?????????????? ?????????????????
• ?????????????????? ????????????????? ?????????

24
Hepatitis E virus (HEV)

• Family Caliciviridae
• ???????????????? RNA , icosahedral capsid
• ??????????????????????? ?????????? 2-9 ???????
• ???????????????????? ??????????????
  ???????????????
• ??????????????????????????????????????????
  ?????????????????????? ?????????????

25
Hepatitis G virus (HGV)

• ???????? Genelabs Technologies ???? 1995
• Family Flaviviridae ???????????????? RNA
• ?????????????? ?????????????????????
• GB agents (GBV-A, GBV-B, GBV-C)
• ???????? Abbott Laboratories ???? 1995
• Family Flaviviridae ???????????????? RNA
• ??????????????